{"id":"W2062220778","doi":"10.1152/ajpcell.00030.2004","title":"The calcium-dependent activity of large-conductance, calcium-activated K<sup>+</sup> channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation","year":2004,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Tyrosine phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Phosphorylation; Cell biology; Chemistry; Tyrosine kinase; Tyrosine-protein kinase CSK; Receptor tyrosine kinase; Signal transduction; SH2 domain; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987868,0.0003379738,0.0002801258,0.000118378,0.0001250778,0.0004179315,0.0001707845,0.0002221921,0.001651374],"category_scores_gemma":[0.0002304199,0.0001207813,0.0003005722,0.0001552116,0.0002380466,0.0003692818,0.0002675142,0.0005090776,0.0004178801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702892,"about_ca_system_score_gemma":0.0001758733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003536154,"about_ca_topic_score_gemma":0.0003762148,"domain_scores_codex":[0.9998192,0.00001794366,0.00001866627,0.00003180624,0.00004939768,0.00006300669],"domain_scores_gemma":[0.9998339,0.00003053226,0.0000494561,0.00001882161,0.00001650792,0.00005064534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737922,0.00001732963,0.0001481067,0.00002339012,0.000003245764,0.00003480893,0.000007902178,0.00002115374,0.9991164,0.00004850074,0.00001958197,0.0003858876],"study_design_scores_gemma":[0.00004160131,0.0002005229,0.01669613,0.000005791525,0.00001135963,0.0004698048,0.00002846111,0.001455268,0.9796447,0.00006996704,0.001369832,0.00000660152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961312,0.001180834,0.001385151,0.00007030366,0.00002694127,0.00001345094,0.0002192275,0.00004699604,0.0009258545],"genre_scores_gemma":[0.9964814,0.0005178477,0.001143118,0.00003973508,0.00002239844,0.00002398444,0.0004791832,0.00002341825,0.001268826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651374,"threshold_uncertainty_score":0.005524397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061447729264762,"score_gpt":0.2544970097637446,"score_spread":0.243882532471097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}