{"id":"W2062280617","doi":"10.1371/journal.pone.0025058","title":"Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Health Sciences Centre","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; AstraZeneca","keywords":"Mucin; Colitis; Mucin 2; Tumor necrosis factor alpha; Immunology; Goblet cell; Ulcerative colitis; Medicine; Inflammatory bowel disease; Pathogenesis; Gastroenterology; Pathology; Biology; Gene expression; Epithelium; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912926,0.000335314,0.0002688156,0.0003436545,0.00009721214,0.0002888322,0.00008282957,0.0002636907,0.0006487982],"category_scores_gemma":[0.0001491085,0.0001334457,0.0001946284,0.0001570321,0.0002323855,0.0002209678,0.0001392279,0.0004549343,0.0002344432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002279576,"about_ca_system_score_gemma":0.000199364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002783851,"about_ca_topic_score_gemma":0.0002669689,"domain_scores_codex":[0.9998926,0.00002233808,0.00001033168,0.00002146123,0.00002223279,0.00003090326],"domain_scores_gemma":[0.999801,0.000009936729,0.00009991563,0.00001291773,0.00002013924,0.00005619226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001219409,0.00005952117,0.004541457,0.00005007489,0.00000727583,0.0002259045,0.00003109816,0.00004371601,0.9894871,0.00006863394,0.00002432921,0.004241541],"study_design_scores_gemma":[0.00009094048,0.004345748,0.2803817,0.00004209473,0.00008808908,0.002768677,0.0002284992,0.001067365,0.7066059,0.0003135877,0.004046647,0.00002059708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893916,0.007701326,0.001959009,0.00009728732,0.00002206511,0.00002999595,0.0001130556,0.00006162,0.0006240243],"genre_scores_gemma":[0.995366,0.002552524,0.0009604935,0.00002340042,0.00001108164,0.00001760009,0.0001050398,0.00000458836,0.0009593876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006487982,"threshold_uncertainty_score":0.002170444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514610248121582,"score_gpt":0.2329012518752437,"score_spread":0.2077551493940278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}