{"id":"W2062280617","doi":"10.1371/journal.pone.0025058","title":"Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Health Sciences Centre","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; AstraZeneca","keywords":"Mucin; Colitis; Mucin 2; Tumor necrosis factor alpha; Immunology; Goblet cell; Ulcerative colitis; Medicine; Inflammatory bowel disease; Pathogenesis; Gastroenterology; Pathology; Biology; Gene expression; Epithelium; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033097,0.0001867056,0.000180267,0.00008565475,0.00004911511,0.00002740031,0.0001003986,0.00009920946,0.00002971036],"category_scores_gemma":[0.00009704701,0.0001864056,0.00002779824,0.00005406747,0.00008746231,0.00001334188,0.0001070829,0.00009897128,0.000004135875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001794339,"about_ca_system_score_gemma":0.00008403417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007077341,"about_ca_topic_score_gemma":0.001030179,"domain_scores_codex":[0.9988288,0.0001012718,0.0002226273,0.0004068532,0.0001337578,0.000306697],"domain_scores_gemma":[0.9993792,0.00000978278,0.00006167206,0.0002414541,0.00003493422,0.0002729604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00156958,0.000972158,0.8103796,0.0001867504,0.00003946607,0.0003893937,0.0007171811,8.352875e-8,0.1853394,0.00001431706,0.000009437533,0.000382615],"study_design_scores_gemma":[0.001362127,0.00009882281,0.8583146,0.0001751335,0.00003104769,0.000002265476,0.00007626291,0.00004212332,0.1395986,0.00008147606,0.000006335731,0.0002112043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988572,0.0003742535,6.958088e-7,0.00004389956,0.00001433694,0.0005144405,0.0001360147,0.00001577132,0.00004340083],"genre_scores_gemma":[0.9993247,0.00008234257,0.0002130945,0.0000959606,0.00002981346,0.0001249586,0.00006742587,0.00002830803,0.00003337148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04793498,"threshold_uncertainty_score":0.7601399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514610248121582,"score_gpt":0.2329012518752437,"score_spread":0.2077551493940278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}