{"id":"W2062282550","doi":"10.3390/v2081752","title":"Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel","year":2010,"lang":"en","type":"article","venue":"Viruses","topic":"Hepatitis C virus research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"","keywords":"NS3; Protease; Hepatitis C virus; Virology; Serine protease; NS2-3 protease; Drug discovery; Biology; Virus; Pharmacology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004696431,0.0001987035,0.000287825,0.00009949038,0.00027184,0.0000357028,0.0003977002,0.0001538478,0.002590285],"category_scores_gemma":[0.001369293,0.0001034029,0.0001801881,0.0004183448,0.000621068,0.0001234811,0.0003922571,0.0006841209,0.0005831946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007766557,"about_ca_system_score_gemma":0.0003365941,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01092186,"about_ca_topic_score_gemma":0.02206562,"domain_scores_codex":[0.9978607,0.0001734667,0.0003910714,0.0002988702,0.0008773972,0.0003985158],"domain_scores_gemma":[0.9981427,0.000219363,0.0001429201,0.001122882,0.0001818534,0.0001902363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122656,0.0001761564,0.233376,0.00006568802,0.00005380995,0.00003027319,0.0004427267,3.863685e-7,0.7363728,0.0002132691,0.02096506,0.008191629],"study_design_scores_gemma":[0.0005276697,0.0001244222,0.05813825,0.00009513254,0.00003796558,0.00002110769,0.00001801808,0.00002244791,0.6743538,0.00009020049,0.266467,0.0001039353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869595,0.0003002996,0.000002603918,0.004229442,0.000458897,0.001304233,0.0001431129,0.00005641995,0.006545505],"genre_scores_gemma":[0.9953598,0.0002843263,0.00008632321,0.00157363,0.0005146282,0.0002005912,0.000004880661,0.00004925622,0.001926576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.245502,"threshold_uncertainty_score":0.9983215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505037604613219,"score_gpt":0.3014884581509131,"score_spread":0.2764380821047809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}