{"id":"W2062298134","doi":"10.1016/j.stem.2011.12.013","title":"Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming","year":2012,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":674,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health","keywords":"Induced pluripotent stem cell; Reprogramming; Biology; Drug discovery; Progenitor cell; Stem cell; Cell biology; Myocyte; Cell; Bioinformatics; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007145848,0.0004094318,0.0004206193,0.0004063091,0.0001404111,0.0003843467,0.0003474963,0.0004167821,0.002339144],"category_scores_gemma":[0.0003947338,0.0002916483,0.0003576277,0.0002361754,0.0002010268,0.0003450715,0.0006480227,0.0008952658,0.001171098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855959,"about_ca_system_score_gemma":0.0002789177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000119501,"about_ca_topic_score_gemma":0.0002742799,"domain_scores_codex":[0.9997,0.00004841882,0.00003185174,0.00007151062,0.0001072763,0.00004109072],"domain_scores_gemma":[0.9997894,0.00006229545,0.00002952062,0.00004578268,0.00002847386,0.00004451176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009192746,0.00003886322,0.0003218436,0.0001162606,0.00001429335,0.0001697324,0.00004740878,0.0002222328,0.9800918,0.00188367,0.0002322293,0.01676975],"study_design_scores_gemma":[0.00004073258,0.0001337831,0.0009175566,0.000009983538,0.00002179518,0.0004570481,0.00001483986,0.0005489221,0.9902377,0.0005129118,0.007098423,0.000006254776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6175687,0.01105154,0.3252885,0.000959951,0.001020067,0.0008887973,0.003220378,0.001189802,0.03881218],"genre_scores_gemma":[0.8708599,0.006469527,0.09943592,0.0003546021,0.0001768782,0.0002908561,0.0024736,0.0002934024,0.0196453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002339144,"threshold_uncertainty_score":0.007825255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594541523999913,"score_gpt":0.2446800585105596,"score_spread":0.2287346432705605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}