{"id":"W2062326815","doi":"10.1093/brain/awn096","title":"Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis","year":2008,"lang":"en","type":"article","venue":"Brain","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":854,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Directorate for Biological Sciences; European Commission; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"OLIG2; Remyelination; Progenitor cell; Multiple sclerosis; Progenitor; Oligodendrocyte; Biology; Pathology; Medicine; Stem cell; Immunology; Cancer research; Myelin; Cell biology; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009000633,0.0001506702,0.0001929235,0.0001640196,0.0001197602,0.00001602108,0.0001701072,0.00008008128,0.00001343698],"category_scores_gemma":[0.0007623811,0.0001531387,0.00009370898,0.0002680585,0.00004975512,0.0001186931,0.00004712648,0.000086153,0.00002099087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007035927,"about_ca_system_score_gemma":0.0001221462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001608133,"about_ca_topic_score_gemma":0.0001413942,"domain_scores_codex":[0.9985796,0.0001353359,0.0003219769,0.0004107502,0.0002865946,0.0002657654],"domain_scores_gemma":[0.999059,0.0004896764,0.0001598965,0.0001844957,0.00004735852,0.00005957061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007554899,0.0001420752,0.0001437879,0.0000329138,0.000002283909,0.00001213627,0.0001459073,0.0002328437,0.9984909,0.0003828011,0.0001733911,0.0001653797],"study_design_scores_gemma":[0.001426776,0.0003216571,0.001693139,0.00002959641,0.000009527455,0.0000242916,0.000006914715,0.007454995,0.9885907,0.00003462156,0.0002754666,0.0001322685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980164,0.000007921108,0.0006127032,0.000182825,0.000262217,0.0008002875,0.00006160135,0.00004698198,0.000009034822],"genre_scores_gemma":[0.9991909,0.00003310288,0.0001937382,0.000145507,0.0001269967,0.00008686934,0.000004484038,0.00003258229,0.0001857989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009900184,"threshold_uncertainty_score":0.6244814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06654343706546649,"score_gpt":0.2567420174795988,"score_spread":0.1901985804141323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}