{"id":"W2062331936","doi":"10.1093/nar/gkp041","title":"The why and how of DNA unlinking","year":2009,"lang":"en","type":"review","venue":"Nucleic Acids Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; DNA; DNA replication; Gene; Genetics; Topoisomerase; Computational biology; DNA sequencing; Genome; Transcription (linguistics); Transcription factor; Cell biology; Topology (electrical circuits)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172639,0.0001867827,0.0004263582,0.00008376735,0.0002263702,0.00009757555,0.0005090822,0.0003396973,0.000006551888],"category_scores_gemma":[0.00007708184,0.0001229567,0.0001828994,0.0001955105,0.0002442088,0.00000160027,0.0003037532,0.0004028374,0.00000307157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000271516,"about_ca_system_score_gemma":0.0002473843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005397624,"about_ca_topic_score_gemma":0.00001475193,"domain_scores_codex":[0.9984348,0.0002726828,0.0001821343,0.0003585275,0.000363975,0.0003878229],"domain_scores_gemma":[0.9989843,0.00007473361,0.0001022482,0.0005898712,0.0001690785,0.00007979287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001158708,0.00001168335,2.500719e-7,0.0006568411,0.00008676312,0.000001530884,0.0000109197,1.803825e-8,0.00245566,0.0006667023,0.001945209,0.9941528],"study_design_scores_gemma":[0.0001067081,0.0003090193,6.861101e-7,0.0006736584,0.00004642542,0.0000141738,0.00003019138,0.000002110819,0.001272839,0.0004067333,0.9970132,0.0001242659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000923602,0.9982267,0.00006222827,0.0002752789,0.0001086878,0.0003862017,0.00001959983,0.000004066622,0.0008248738],"genre_scores_gemma":[0.0003447026,0.9973199,0.0001026376,0.00004892007,0.0002907404,0.00003163759,0.00003557137,0.00004062138,0.001785268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995068,"threshold_uncertainty_score":0.501403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09144066689703069,"score_gpt":0.3956419820969787,"score_spread":0.304201315199948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}