{"id":"W2062332342","doi":"10.1038/icb.2009.39","title":"X chromosome reactivation perturbs intracellular self/not‐self discrimination","year":2009,"lang":"en","type":"review","venue":"Immunology and Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"X chromosome; Immune system; Dosage compensation; Intracellular; Chromosome; Biology; Self Tolerance; Gene; Disease; Autoimmune disease; Genetics; Immunology; Hormone; Cell biology; Autoimmunity; Antibody; Medicine; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0006214133,0.001400406,0.003300243,0.0007992289,0.0007068181,0.00004565151,0.0009916375,0.005498167,0.0005650458],"category_scores_gemma":[0.0001016643,0.001147306,0.0006313404,0.0004196615,0.0009967719,0.0002200365,0.000444878,0.002657314,0.001921882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688199,"about_ca_system_score_gemma":0.0003724445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007997154,"about_ca_topic_score_gemma":0.000008143028,"domain_scores_codex":[0.9931092,0.002124067,0.001581287,0.001718296,0.00005528843,0.001411886],"domain_scores_gemma":[0.9965665,0.0008627988,0.001211581,0.001140675,0.0001536589,0.00006480508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009338302,0.0007427298,0.000006527533,0.001311751,0.001305985,0.00003334331,0.0004256833,5.867053e-8,0.4496586,0.003187299,0.0005411729,0.5426935],"study_design_scores_gemma":[0.001493142,0.001170898,0.00002002135,0.0006272228,0.001564602,0.0008550877,0.00009841151,8.992657e-7,0.03068222,0.0004251203,0.9619125,0.001149888],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004249821,0.988562,0.00003595649,0.0002082477,0.002725027,0.001197551,0.00009216797,0.0006121725,0.002317077],"genre_scores_gemma":[0.01218129,0.9797663,0.0001578077,0.0002153382,0.0002020565,0.0002250897,0.003612272,0.0001073637,0.003532486],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9613713,"threshold_uncertainty_score":0.9998747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651174358885225,"score_gpt":0.2491414493655328,"score_spread":0.2326297057766806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}