{"id":"W2062389087","doi":"10.1101/pdb.prot5011","title":"Construction and Characterization of Adenovirus Vectors","year":2009,"lang":"en","type":"article","venue":"Cold Spring Harbor Protocols","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Transduction (biophysics); Transgene; Plasmid; Biology; Gene delivery; Vector (molecular biology); Cloning (programming); Gene; Genetic enhancement; Computational biology; Viral vector; In vivo; Transfection; Genome; Cloning vector; Genetics; Recombinant DNA; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477171,0.00008782229,0.0001034918,0.00004878545,0.00004321869,0.00002084555,0.00009476741,0.00008101248,0.00001171628],"category_scores_gemma":[0.00002637882,0.00009215594,0.00002813925,0.00008062118,0.00006336968,0.000005370489,0.0000287738,0.00005906519,0.000002243353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001047472,"about_ca_system_score_gemma":0.00005622656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001933971,"about_ca_topic_score_gemma":0.000001449081,"domain_scores_codex":[0.9993573,0.0000419762,0.0001497811,0.0001995184,0.0001106996,0.0001407326],"domain_scores_gemma":[0.9995673,0.000003248892,0.00007907399,0.0002271311,0.00007014221,0.00005309321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005176354,0.00003398059,0.002496241,0.00002402648,0.00001104166,6.229573e-7,0.000006250279,0.000001634091,0.9936064,0.0004315058,0.000004138287,0.002866458],"study_design_scores_gemma":[0.0004968015,0.00151895,0.03044478,0.00003305909,0.000002842147,6.448607e-7,0.000001299924,0.00001542528,0.962199,0.000008604056,0.005187307,0.00009130217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880657,0.00003906808,0.0003853648,0.00005221972,0.00001706519,0.01137108,0.000006425124,0.00001405497,0.00004900237],"genre_scores_gemma":[0.9954029,0.00002315105,0.0003663953,0.00006763093,0.00009845362,0.003995747,0.000002987593,0.00001269941,0.00003006917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03140748,"threshold_uncertainty_score":0.375801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600136121852969,"score_gpt":0.2933106057832059,"score_spread":0.2773092445646762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}