{"id":"W2062436518","doi":"10.1016/s0006-2952(01)00537-8","title":"Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines11Abbreviations: DT-diaphorase, NAD(P)H:(quinone acceptor)oxidoreductase; ARE, antioxidant response element; MMC, mitomycin C; EO9, 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione)prop-β-en-α-ol; D3T, 1,2-dithiole-3-thione; SSC, 0.15 M sodium chloride, 0.015 M sodium citrate buffer solution; and PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; Medical Research Council Canada; American Institute for Cancer Research","keywords":"Molecular biology; Mutant; NAD+ kinase; Cell culture; Transfection; Diaphorase; Biochemistry; Biology; Enzyme; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832526,0.0003236468,0.0002574543,0.0004526691,0.0002225574,0.0003930338,0.0001242347,0.00020725,0.00354351],"category_scores_gemma":[0.0002586633,0.0002359124,0.0002006801,0.0004115222,0.0002184161,0.0001651683,0.0001759275,0.0004342648,0.0009552703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003892985,"about_ca_system_score_gemma":0.0002519923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00158556,"about_ca_topic_score_gemma":0.003807278,"domain_scores_codex":[0.9998237,0.00003428003,0.00002207736,0.00004324204,0.00002819914,0.00004843355],"domain_scores_gemma":[0.9997485,0.0001194729,0.00004052788,0.00003290538,0.00002414854,0.00003441466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111621,0.00003122899,0.0006424181,0.00002392604,0.000003343572,0.00005284269,0.00002904371,0.0000213016,0.9984792,0.00005292075,0.00003875514,0.0005139053],"study_design_scores_gemma":[0.00001532564,0.0002860996,0.0321679,0.000006231832,0.00002095262,0.0003560421,0.00007269644,0.0002937654,0.9643078,0.0000463021,0.002421732,0.000005222387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991618,0.001792158,0.002316806,0.00007370215,0.00003491048,0.000062409,0.002009567,0.00007674505,0.002015875],"genre_scores_gemma":[0.9889326,0.001278426,0.001493154,0.00003764149,0.00001269557,0.00006844557,0.004712293,0.00002988729,0.003434781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00354351,"threshold_uncertainty_score":0.01185417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688557539696455,"score_gpt":0.2711403533283589,"score_spread":0.2542547779313943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}