{"id":"W2062436518","doi":"10.1016/s0006-2952(01)00537-8","title":"Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines11Abbreviations: DT-diaphorase, NAD(P)H:(quinone acceptor)oxidoreductase; ARE, antioxidant response element; MMC, mitomycin C; EO9, 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione)prop-β-en-α-ol; D3T, 1,2-dithiole-3-thione; SSC, 0.15 M sodium chloride, 0.015 M sodium citrate buffer solution; and PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; Medical Research Council Canada; American Institute for Cancer Research","keywords":"Molecular biology; Mutant; NAD+ kinase; Cell culture; Transfection; Diaphorase; Biochemistry; Biology; Enzyme; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001791172,0.001141684,0.001154323,0.0006499084,0.0006028569,0.00008731987,0.0006929496,0.0009559732,0.00009375472],"category_scores_gemma":[0.000543306,0.001067428,0.0004029454,0.0009792168,0.0007973297,0.000140731,0.000505962,0.001446425,0.00001092115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005586858,"about_ca_system_score_gemma":0.0004187972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006785,"about_ca_topic_score_gemma":0.0000445019,"domain_scores_codex":[0.9928188,0.001616626,0.001709828,0.001882128,0.0006839528,0.00128866],"domain_scores_gemma":[0.9960915,0.0004276036,0.001561099,0.0008655521,0.0004836071,0.0005706222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003434339,0.001666167,0.002727279,0.0001588847,0.0002554666,0.00002488285,0.0003188276,0.00003970468,0.9788218,0.000007803429,0.01240231,0.0001425113],"study_design_scores_gemma":[0.004655757,0.0004864455,0.01430757,0.00009071158,0.000268818,0.00004808014,0.0008438776,0.0001354134,0.9759233,0.00008689327,0.002106871,0.001046287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877043,0.00675615,0.0003531927,0.001512893,0.001280292,0.001694044,0.0005624714,0.00009562964,0.00004097166],"genre_scores_gemma":[0.992751,0.003387299,0.0001723483,0.0006202729,0.001486486,0.0004158726,0.0008488001,0.0001305608,0.0001873861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01158029,"threshold_uncertainty_score":0.9991776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688557539696455,"score_gpt":0.2711403533283589,"score_spread":0.2542547779313943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}