{"id":"W2062437994","doi":"10.1074/jbc.m310726200","title":"Novel Nuclear Shuttle Proteins, HDBP1 and HDBP2, Bind to Neuronal Cell-specific cis-Regulatory Element in the Promoter for the Human Huntington's Disease Gene","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ministry of Education, Culture, Sports, Science and Technology; University of Ottawa","keywords":"Biology; Nuclear localization sequence; Molecular biology; Nuclear export signal; Nuclear protein; Gene; Huntingtin; Exon; Transcription factor; Promoter; Mutant; Cell nucleus; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371297,0.0006935747,0.0003323608,0.0002338543,0.000245644,0.0003280615,0.0002418929,0.0003443916,0.001470274],"category_scores_gemma":[0.0001851037,0.0002344012,0.000267349,0.0001667491,0.0003038354,0.0002320899,0.0003468051,0.0004136105,0.0006113016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003976964,"about_ca_system_score_gemma":0.0002406541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005194353,"about_ca_topic_score_gemma":0.0009390112,"domain_scores_codex":[0.999866,0.00001131096,0.000005130947,0.00005391465,0.00003940043,0.00002417657],"domain_scores_gemma":[0.9998859,0.00001748845,0.00002974656,0.000008260032,0.00001643981,0.0000420235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001626999,0.0000291149,0.0006806893,0.00006111327,0.000008262842,0.0001173702,0.00003139994,0.00004647687,0.9970149,0.0001373336,0.00006366111,0.001646925],"study_design_scores_gemma":[0.0001822587,0.0005871623,0.05744229,0.00003768151,0.00008976663,0.003495788,0.0001768901,0.003463627,0.9172458,0.0003365233,0.01690883,0.00003336713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809313,0.00613001,0.01091504,0.0001437687,0.00007670672,0.00004674062,0.0005066061,0.000182572,0.001067318],"genre_scores_gemma":[0.9826245,0.001681769,0.006950372,0.00008025698,0.0000326953,0.00007785973,0.003085356,0.00003461,0.005432718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470274,"threshold_uncertainty_score":0.004918516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106294724107086,"score_gpt":0.260463720228406,"score_spread":0.2194007729873351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}