{"id":"W2062464623","doi":"10.1074/jbc.m009782200","title":"Major Photoaffinity Drug Binding Sites in Multidrug Resistance Protein 1 (MRP1) Are within Transmembrane Domains 10–11 and 16–17","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Photoaffinity labeling; Linker; Transmembrane domain; Efflux; ATP-binding cassette transporter; Transmembrane protein; Biochemistry; Binding site; Peptide; Multiple drug resistance; Epitope; Peptide sequence; Chemistry; Biology; Amino acid; Transporter; Gene; Genetics; Receptor; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812321,0.0003656439,0.0003955045,0.0001987288,0.0003403002,0.0003080005,0.0004259721,0.0005085388,0.002091755],"category_scores_gemma":[0.0001955589,0.0003606511,0.0005410956,0.0002349747,0.0003882113,0.0003019422,0.0002023169,0.0007302636,0.001142144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004991721,"about_ca_system_score_gemma":0.0001727309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007855952,"about_ca_topic_score_gemma":0.001154139,"domain_scores_codex":[0.9997846,0.00003812434,0.00001058662,0.00006038227,0.00006837772,0.00003789763],"domain_scores_gemma":[0.9997914,0.0000638183,0.00006443488,0.00002536949,0.00002540624,0.00002953298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002644458,0.000008095427,0.0001952155,0.00003622815,0.000004676448,0.00004167465,0.00001327471,0.00002392484,0.9986196,0.00004839824,0.00002628317,0.0009563474],"study_design_scores_gemma":[0.00000669261,0.0001320931,0.008569883,0.000005572911,0.00001689781,0.0006934172,0.00002832837,0.0003303384,0.9872083,0.00004791592,0.002950302,0.00001018508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820521,0.00315795,0.01159486,0.0001806477,0.00003598668,0.00006590708,0.0003798196,0.0001483178,0.002384402],"genre_scores_gemma":[0.9751061,0.001789683,0.01880739,0.0001570628,0.00001471359,0.00006020794,0.001143152,0.00004518165,0.00287643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091755,"threshold_uncertainty_score":0.006997645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039708261367058,"score_gpt":0.2463256243234448,"score_spread":0.2259285417097742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}