{"id":"W2062476040","doi":"10.1182/blood-2002-01-0316","title":"Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPARα","year":2002,"lang":"en","type":"article","venue":"Blood","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; American Heart Association; Brigham and Women's Hospital; American Diabetes Association","keywords":"Eicosapentaenoic acid; Fish oil; Polyunsaturated fatty acid; Peroxisome proliferator-activated receptor; Peroxisome proliferator-activated receptor alpha; Lipopolysaccharide; Docosahexaenoic acid; Receptor; Chemistry; Nitric oxide; Biochemistry; Peroxisome; Fatty acid; Pharmacology; Biology; Nuclear receptor; Endocrinology; Transcription factor; Fish <Actinopterygii>","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007701622,0.0001858153,0.0002182246,0.00008549136,0.00005379562,0.00001898734,0.0001670039,0.0001926954,0.0001379666],"category_scores_gemma":[0.0001592895,0.0001883603,0.0001033479,0.00023281,0.00007149924,0.0000284656,0.00008376935,0.0002053189,0.0000165139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003237763,"about_ca_system_score_gemma":0.00003945347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003544751,"about_ca_topic_score_gemma":0.00004790422,"domain_scores_codex":[0.9988396,0.00008568,0.0003375251,0.0003369898,0.0001504615,0.0002497511],"domain_scores_gemma":[0.9994007,0.000022389,0.0001480905,0.0003003142,0.00007726424,0.00005121616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001077562,0.0006461319,0.004301991,0.00002103501,0.00007815939,0.000001615011,0.00018429,0.00001970199,0.9935287,0.00001451645,0.0004611594,0.0006349036],"study_design_scores_gemma":[0.002997818,0.000134058,0.0003912962,0.00004193814,0.00001960526,0.00001317779,0.00007613892,0.0000214675,0.983738,0.0000180815,0.01235927,0.0001891232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957723,0.0001006129,0.0001136208,0.0001828896,0.0001532873,0.0001011178,0.00003497267,0.00002381143,0.00351736],"genre_scores_gemma":[0.9978645,0.0003505909,0.0006966277,0.0001835406,0.0002097624,0.00005215602,0.00007665255,0.00002983116,0.0005363109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01189811,"threshold_uncertainty_score":0.7681111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732746920532231,"score_gpt":0.2460972173337273,"score_spread":0.2287697481284049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}