{"id":"W2062511407","doi":"10.1371/journal.pgen.1002245","title":"Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; National Human Genome Research Institute; Massachusetts General Hospital; Ovarian Cancer Research Fund; Canadian Institutes of Health Research; Avon Foundation for Women","keywords":"Genome instability; Biology; Carcinogenesis; DNA damage; Proliferating cell nuclear antigen; Cancer research; Mutation; DNA repair; Genetics; Somatic cell; DNA mismatch repair; Nonsense mutation; Germline mutation; Molecular biology; Cancer; Gene; DNA; Missense mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408142,0.0006000298,0.0002336751,0.0008731393,0.0002143172,0.0001919509,0.0002074922,0.0004733525,0.002741229],"category_scores_gemma":[0.0002041383,0.0002150735,0.0002839497,0.0003653832,0.0002395781,0.000108613,0.0004617441,0.0003141539,0.0003183147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001795143,"about_ca_system_score_gemma":0.000142929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005445051,"about_ca_topic_score_gemma":0.0007869172,"domain_scores_codex":[0.9998178,0.00003350311,0.0000286129,0.00005944198,0.0000357168,0.00002495673],"domain_scores_gemma":[0.9998272,0.00002774545,0.00007269333,0.00001919955,0.000006445903,0.00004676055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002673112,0.00003435725,0.007301155,0.00005085232,0.00003092484,0.001333117,0.00002447612,0.0001542835,0.9880542,0.0003862545,0.0001168247,0.002246137],"study_design_scores_gemma":[0.0001495262,0.001043165,0.2824894,0.00006759447,0.0003035299,0.04751702,0.0002584209,0.005122493,0.6484542,0.0008174322,0.01371763,0.00005962415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945542,0.0008876481,0.002552417,0.00007104314,0.00002003654,0.00002433694,0.0006461797,0.0001220054,0.001122139],"genre_scores_gemma":[0.9970155,0.0004269504,0.001218883,0.00003630078,0.000007739607,0.00001393838,0.0003747314,0.0000157949,0.000890271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002741229,"threshold_uncertainty_score":0.009170294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808652688571342,"score_gpt":0.2175708908050398,"score_spread":0.1994843639193264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}