{"id":"W2062547744","doi":"10.1021/bi015829k","title":"Thermodynamic Binding Parameters of Individual Epitopes of Multivalent Carbohydrates to Concanavalin A As Determined by “Reverse” Isothermal Titration Microcalorimetry","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"thermodynamics and calorimetric analyses","field":"Chemistry","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Epitope; Isothermal microcalorimetry; Chemistry; Lectin; Titration; Concanavalin A; Isothermal titration calorimetry; Binding constant; Divalent; Cooperativity; Binding site; Stereochemistry; Biochemistry; Enthalpy; Thermodynamics; Organic chemistry; Antigen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005018177,0.0003258068,0.0003115227,0.0003050937,0.0002004646,0.0003575222,0.0005275332,0.0002817274,0.001359783],"category_scores_gemma":[0.00124533,0.0002297007,0.0002371224,0.0003089389,0.0004303889,0.0002565604,0.0001914673,0.0008577842,0.0004121004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902813,"about_ca_system_score_gemma":0.0002514985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001886212,"about_ca_topic_score_gemma":0.001291669,"domain_scores_codex":[0.9996039,0.00006135798,0.0000163614,0.00008867999,0.0001789568,0.00005076917],"domain_scores_gemma":[0.9996362,0.0001847661,0.00005827639,0.0000222223,0.00006547001,0.00003311353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008538903,0.00003109989,0.0009338664,0.00003324676,0.000008549541,0.0000101605,0.0000508361,0.000979943,0.9954756,0.0001926014,0.00006870867,0.002129922],"study_design_scores_gemma":[0.000006358351,0.0001578474,0.005192013,0.000003634261,0.000009600796,0.00003731476,0.00003302863,0.02116083,0.9726155,0.0001338308,0.0006309999,0.00001906273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887698,0.0004695012,0.009032399,0.00005579478,0.00001664802,0.00003421201,0.0002115909,0.0001211078,0.001289068],"genre_scores_gemma":[0.9955302,0.0003023832,0.002961605,0.00003275857,0.000008027411,0.00005544601,0.0002521148,0.00002520096,0.000832196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886212,"threshold_uncertainty_score":0.004548967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142492500410963,"score_gpt":0.2488602380076194,"score_spread":0.2374353130035098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}