{"id":"W2062547744","doi":"10.1021/bi015829k","title":"Thermodynamic Binding Parameters of Individual Epitopes of Multivalent Carbohydrates to Concanavalin A As Determined by “Reverse” Isothermal Titration Microcalorimetry","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"thermodynamics and calorimetric analyses","field":"Chemistry","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Epitope; Isothermal microcalorimetry; Chemistry; Lectin; Titration; Concanavalin A; Isothermal titration calorimetry; Binding constant; Divalent; Cooperativity; Binding site; Stereochemistry; Biochemistry; Enthalpy; Thermodynamics; Organic chemistry; Antigen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001549264,0.0002928606,0.0004257796,0.0001241794,0.00005103915,0.00002614457,0.0004742946,0.0002548458,0.0003453216],"category_scores_gemma":[0.0001420242,0.0002917627,0.0002082935,0.0004535604,0.0001379037,0.00005274677,0.0000962775,0.0001562291,0.00001051378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213144,"about_ca_system_score_gemma":0.0001110942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006726612,"about_ca_topic_score_gemma":0.000009449485,"domain_scores_codex":[0.9982725,0.00002289864,0.0005623892,0.0004193865,0.000395024,0.0003278455],"domain_scores_gemma":[0.9988176,0.0001384443,0.0003661873,0.0004099207,0.0001035937,0.0001642303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144471,0.00016432,0.003121163,0.0001236682,0.0002250867,0.000007337021,0.0001466659,0.000018663,0.9916536,0.00000675721,0.000148934,0.004269324],"study_design_scores_gemma":[0.0005855998,0.0000559459,0.0002491451,0.0001000178,0.0001391564,0.000009432263,0.0006755475,0.001191697,0.9965721,0.00002155026,0.00008705577,0.0003127175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966418,0.0004510108,0.0001720877,0.00003260326,0.00005503865,0.00009354844,0.0003914911,0.00003689787,0.002125527],"genre_scores_gemma":[0.998028,0.00006260652,0.0006464168,0.00004391188,0.00005444464,0.00001527417,0.0001997103,0.00004020449,0.0009094014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004918501,"threshold_uncertainty_score":0.9999534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142492500410963,"score_gpt":0.2488602380076194,"score_spread":0.2374353130035098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}