{"id":"W2062618220","doi":"10.1074/jbc.m002169200","title":"Glycogen Synthase Kinase 3β Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Saskatchewan","funders":"","keywords":"HSF1; Heat shock factor; GSK-3; Heat shock protein; Transcription factor; Heat shock; Transcription (linguistics); Cell biology; Transcriptional regulation; Biology; Hsp70; Molecular biology; Glycogen synthase; Chemistry; Phosphorylation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006977296,0.0003666512,0.0001633707,0.0001547389,0.0001201357,0.0002241493,0.00008899144,0.00008138581,0.001216513],"category_scores_gemma":[0.00009454317,0.0001042616,0.0001710187,0.00009167015,0.0001876199,0.0001087746,0.0001866659,0.0002681081,0.0003190022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002350244,"about_ca_system_score_gemma":0.0002182142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004505088,"about_ca_topic_score_gemma":0.0009734125,"domain_scores_codex":[0.9999551,0.000008334876,0.000003347658,0.000009562501,0.000009643375,0.00001405508],"domain_scores_gemma":[0.9999536,0.000005468291,0.00001572493,0.000004724624,0.000004737311,0.00001563653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002117701,0.00001645609,0.0006271466,0.00004077274,0.000006501632,0.00005840463,0.000009713797,0.00006096304,0.9970493,0.0001186529,0.000100707,0.001699685],"study_design_scores_gemma":[0.00008304221,0.0002765361,0.04471054,0.0000232131,0.00003210533,0.0004828214,0.00005436809,0.001357216,0.9487782,0.0003679433,0.003824914,0.00000916261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886614,0.006509449,0.001756714,0.0001851263,0.00007102232,0.00001476973,0.0003371936,0.0001333197,0.002330945],"genre_scores_gemma":[0.9948152,0.002194649,0.0004572401,0.00005628348,0.00001239588,0.00002129844,0.0003527924,0.0000145457,0.002075612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216513,"threshold_uncertainty_score":0.004069626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692756043912917,"score_gpt":0.2774677441146747,"score_spread":0.2505401836755455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}