{"id":"W2062618306","doi":"10.1073/pnas.0706367104","title":"Human cone photoreceptor dependence on RPE65 isomerase","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Alcon Research Institute; National Institutes of Health; National Eye Institute; Hope For Vision; Macula Vision Research Foundation","keywords":"RPE65; Visual phototransduction; Cis-trans-Isomerases; Electroretinography; Biology; Retina; Retinal pigment epithelium; Retinal; Cell biology; Neuroscience; Genetics; Biochemistry; Isomerase; Peptidylprolyl isomerase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008331544,0.00006402512,0.00006363645,0.00006381418,0.0001289514,0.000008597439,0.0004169867,0.000065666,0.00001751117],"category_scores_gemma":[0.0002008416,0.00004427699,0.00004405388,0.0002111108,0.0004216074,0.00001093213,0.00007155996,0.00006200399,0.000001552324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007824502,"about_ca_system_score_gemma":0.00001911056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002570362,"about_ca_topic_score_gemma":1.46765e-7,"domain_scores_codex":[0.998989,0.000002027201,0.0001767096,0.0001736804,0.000543265,0.0001152772],"domain_scores_gemma":[0.9996502,0.00001389021,0.0001770735,0.00000541157,0.0001268418,0.00002662099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002437915,0.00002983848,0.009638409,0.00001014939,0.000006115117,2.522422e-9,0.00002458286,0.000004354762,0.9831814,0.005516593,0.001330181,0.0002340478],"study_design_scores_gemma":[0.0001361379,0.00008709339,0.06765726,0.00002371445,0.000002196182,0.000001514587,0.00009189371,0.00000522672,0.9277973,0.003063965,0.00107338,0.00006035165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792569,0.0000772612,0.000001320319,0.0004108958,0.00001484883,0.00008552484,0.000002978217,0.000002572841,0.02014764],"genre_scores_gemma":[0.9985815,0.0000211101,0.0004500261,0.0004164126,0.00005235603,0.000002635894,3.350413e-7,0.00000240737,0.0004732133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05801886,"threshold_uncertainty_score":0.1805563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565139987519709,"score_gpt":0.3110985598865147,"score_spread":0.2854471600113176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}