{"id":"W2062618306","doi":"10.1073/pnas.0706367104","title":"Human cone photoreceptor dependence on RPE65 isomerase","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Alcon Research Institute; National Institutes of Health; National Eye Institute; Hope For Vision; Macula Vision Research Foundation","keywords":"RPE65; Visual phototransduction; Cis-trans-Isomerases; Electroretinography; Biology; Retina; Retinal pigment epithelium; Retinal; Cell biology; Neuroscience; Genetics; Biochemistry; Isomerase; Peptidylprolyl isomerase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478076,0.0001920456,0.0001468601,0.0002519781,0.0001909473,0.0003195854,0.00009792164,0.0001720768,0.002381068],"category_scores_gemma":[0.0002013297,0.0001080653,0.0002000302,0.0001730337,0.0001607048,0.0001016573,0.0001543291,0.0001722681,0.001307759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002740342,"about_ca_system_score_gemma":0.000157568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002621572,"about_ca_topic_score_gemma":0.002308388,"domain_scores_codex":[0.9998602,0.00001704979,0.00001415771,0.00003885667,0.00004458552,0.0000252006],"domain_scores_gemma":[0.999886,0.00002202604,0.00001805517,0.00003252556,0.00002304025,0.00001841213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105191,0.00001760535,0.001829298,0.00002568841,0.000008228004,0.0002705634,0.0000453195,0.00002265984,0.9941964,0.000164338,0.0001376527,0.003176948],"study_design_scores_gemma":[0.00003642427,0.0005233823,0.1530543,0.0000343905,0.00006416871,0.01069069,0.0001915601,0.0009146087,0.8095025,0.0003343686,0.02463052,0.00002309331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884753,0.002991812,0.002264411,0.0000909646,0.00002407792,0.00002562745,0.001036459,0.00009922947,0.004992146],"genre_scores_gemma":[0.993262,0.00110106,0.001094707,0.00005912452,0.000004754108,0.00001404088,0.001900742,0.00002580568,0.002537744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002621572,"threshold_uncertainty_score":0.007965446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565139987519709,"score_gpt":0.3110985598865147,"score_spread":0.2854471600113176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}