{"id":"W2062644850","doi":"10.1016/j.bbrc.2007.12.015","title":"AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes","year":2007,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Retromer; Endosome; Golgi apparatus; Cell biology; Transport protein; Signal transducing adaptor protein; Endocytosis; Chemistry; Biology; Biochemistry; Phosphorylation; Endoplasmic reticulum; Receptor; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001531018,0.00008675471,0.0001294694,0.00003208204,0.0002573121,0.00003826042,0.0004819699,0.0001022131,7.336458e-7],"category_scores_gemma":[0.0001189848,0.00004321649,0.00004949166,0.000214121,0.002054694,0.000004537854,0.0002288304,0.0003588755,3.989033e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004425379,"about_ca_system_score_gemma":0.00001789734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008068434,"about_ca_topic_score_gemma":0.00007510252,"domain_scores_codex":[0.9989462,0.0002478855,0.0002060089,0.0001796184,0.0002162008,0.0002041208],"domain_scores_gemma":[0.9986911,0.0005857541,0.0000369664,0.0005667759,0.0000636428,0.00005574728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001433268,0.00007028208,0.003705724,0.00001545428,0.00002535008,3.32292e-7,0.0006691866,1.040948e-7,0.9888229,0.003732497,0.00003169723,0.002783176],"study_design_scores_gemma":[0.002668454,0.0004369456,0.3557185,0.0001189702,0.000125716,0.0000155415,0.00421252,0.0005890745,0.6148435,0.003242675,0.01764209,0.0003859874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898304,0.006386023,0.00009744107,0.0031191,0.000003449769,0.0002577442,0.00001165383,0.000002584122,0.0002915481],"genre_scores_gemma":[0.9963758,0.003188876,0.00007527533,0.00005551862,0.00006830714,0.00001954709,0.0001927985,0.000005435048,0.00001843062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3739793,"threshold_uncertainty_score":0.7570605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04120494567286053,"score_gpt":0.3359952246873313,"score_spread":0.2947902790144708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}