{"id":"W2062647481","doi":"10.1371/journal.pone.0118862","title":"Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Natural Science Foundation of China","keywords":"Haplotype; Single-nucleotide polymorphism; Odds ratio; Medicine; Case-control study; Nested case-control study; Genotype; Tuberculosis; Genotyping; Population; Genetics; Internal medicine; Biology; Pathology; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001992468,0.0002824623,0.001012092,0.001177219,0.0001028763,0.00002170046,0.0001566395,0.0003330716,0.0001289948],"category_scores_gemma":[0.0002269938,0.0003072352,0.000090699,0.00192018,0.00008543716,0.000217842,0.00007493396,0.0008067949,0.00001334293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852165,"about_ca_system_score_gemma":0.0000998313,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01110708,"about_ca_topic_score_gemma":0.02432138,"domain_scores_codex":[0.9963669,0.001617787,0.0007310907,0.0004924126,0.0003344605,0.0004573642],"domain_scores_gemma":[0.9986123,0.0004089308,0.0002432514,0.0002912199,0.0001713082,0.0002730102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003221273,0.0071117,0.8992873,0.00003732994,0.002477842,0.0008148896,0.006517621,0.0006947261,0.08008723,0.0000100916,0.000005344092,0.002633743],"study_design_scores_gemma":[0.008804523,0.0007478992,0.8181344,0.00005251827,0.004685156,0.00004775504,0.001213719,0.0539159,0.1117695,0.00008804463,0.00001487214,0.0005257655],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970582,0.0002203636,0.0000109813,0.0003759772,0.0001286034,0.001723414,0.0002695083,0.0000530747,0.0001598642],"genre_scores_gemma":[0.9991035,0.0001221615,0.00008855692,0.0003025813,0.00005755947,0.0002401211,0.00001921251,0.00002706049,0.00003924241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.081153,"threshold_uncertainty_score":0.999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1681802349324107,"score_gpt":0.3689326017382927,"score_spread":0.2007523668058819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}