{"id":"W2062647997","doi":"10.1074/jbc.m007352200","title":"Calpain Mutants with Increased Ca2+ Sensitivity and Implications for the Role of the C2-like Domain","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Mutant; Sensitivity (control systems); Domain (mathematical analysis); Chemistry; Cell biology; Biophysics; Biochemistry; Biology; Gene; Engineering; Mathematics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692783,0.0004959248,0.0002291977,0.0001487127,0.0001311922,0.0002974697,0.0004369223,0.0005476387,0.0006604094],"category_scores_gemma":[0.0002596697,0.0001406554,0.0004153482,0.000176876,0.0002605091,0.0001249635,0.0002082306,0.0005773935,0.0001842745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024917,"about_ca_system_score_gemma":0.0002047832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173009,"about_ca_topic_score_gemma":0.0009195642,"domain_scores_codex":[0.9998522,0.0000259826,0.00003027314,0.00002603289,0.0000425592,0.00002291032],"domain_scores_gemma":[0.9997711,0.00006353488,0.00007794001,0.00002207694,0.00002407985,0.0000413739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007207536,0.00002565186,0.0001186776,0.0000156907,0.000005790454,0.0001078457,0.00000995056,0.00009428988,0.9992543,0.00003981925,0.00001205836,0.000243766],"study_design_scores_gemma":[0.00003892392,0.0001961488,0.00342816,0.00000663482,0.00002448088,0.0007127697,0.00002459189,0.0009915775,0.9939024,0.0000345889,0.0006321575,0.000007478248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979564,0.0003352604,0.001128453,0.00005415982,0.00001474464,0.00002127432,0.0001881304,0.00002548306,0.0002760627],"genre_scores_gemma":[0.9964831,0.0002593497,0.002174787,0.00006104055,0.000008994221,0.00002425422,0.00035859,0.0000231151,0.0006066042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173009,"threshold_uncertainty_score":0.002332389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008741645617546926,"score_gpt":0.22512707263844,"score_spread":0.216385427020893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}