{"id":"W2062677397","doi":"10.1016/j.phrs.2010.07.004","title":"Influence of peroxisome proliferator-activated receptor-alpha (PPARα) activity on adverse effects associated with amiodarone exposure in mice","year":2010,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Dalhousie University","funders":"Canadian Institutes of Health Research; Research Nova Scotia","keywords":"Peroxisome proliferator-activated receptor; Peroxisome proliferator-activated receptor alpha; Peroxisome proliferator; Alpha (finance); Peroxisome; Chemistry; Pharmacology; Amiodarone; Adverse effect; Endocrinology; Internal medicine; Receptor; Nuclear receptor; Medicine; Biochemistry; Transcription factor; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00175818,0.0003997361,0.000496945,0.0003015301,0.0001916311,0.00002808355,0.000657093,0.0006787125,0.0001359609],"category_scores_gemma":[0.003242326,0.0003112727,0.00009628164,0.001118334,0.0007101323,0.00003978231,0.0003053874,0.002332768,0.00003707542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681273,"about_ca_system_score_gemma":0.0004060237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004274404,"about_ca_topic_score_gemma":0.00004823399,"domain_scores_codex":[0.9953939,0.001315994,0.000382707,0.0009357705,0.0009404485,0.00103118],"domain_scores_gemma":[0.997873,0.0005213917,0.0001925696,0.0003852886,0.0006406897,0.0003870501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00383307,0.001733335,0.03465245,0.00005019469,0.000133598,0.00002970035,0.00005706579,0.0003716913,0.958164,0.00001815791,0.0002422608,0.0007144842],"study_design_scores_gemma":[0.00283182,0.003203829,0.06141884,0.0000744428,0.00001371801,0.000003604924,0.00002381907,0.00003677792,0.931485,0.00001438128,0.0005611763,0.0003326026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978793,0.00005935036,0.000003231439,0.0001796184,0.000122313,0.001319627,0.00003816431,0.00005135269,0.0003470721],"genre_scores_gemma":[0.9988115,0.0001114735,0.00007962105,0.0001526813,0.0001464085,0.0004374917,0.00004747663,0.00005313524,0.0001601417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02676639,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588480188631726,"score_gpt":0.3435902135166591,"score_spread":0.3177054116303418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}