{"id":"W2062686953","doi":"10.1097/00001813-200504000-00009","title":"In vivo efficacy and toxicity of intratumorally delivered mitomycin C and its combination with doxorubicin using microsphere formulations","year":2005,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Doxorubicin; Toxicity; Mitomycin C; Microsphere; In vivo; Therapeutic index; Pharmacology; Chemotherapy; Medicine; Dextran; Chemistry; Surgery; Drug; Internal medicine; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004852744,0.0005967137,0.00053529,0.0004566098,0.0001600181,0.0002549,0.0002844591,0.0004697418,0.0006453042],"category_scores_gemma":[0.0002336198,0.000184258,0.0002932931,0.0003327813,0.0002673857,0.0002794032,0.0001156969,0.0005927899,0.0001660222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003349344,"about_ca_system_score_gemma":0.0004132832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008626542,"about_ca_topic_score_gemma":0.001134526,"domain_scores_codex":[0.9997544,0.00006179122,0.00002039338,0.00005271269,0.00005075299,0.00005999901],"domain_scores_gemma":[0.9998185,0.00005172431,0.00004887963,0.00002028397,0.00001941898,0.00004123818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007758077,0.0002869734,0.0001734848,0.00005067895,0.00001498253,0.00004023928,0.00002285704,0.0002436007,0.9962567,0.00004421148,0.00004509251,0.002045407],"study_design_scores_gemma":[0.00005922011,0.006138526,0.001186641,0.000004152471,0.00004431229,0.00009586463,0.000007630887,0.001139172,0.9907634,0.00001396491,0.000539845,0.000007421446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941018,0.002219677,0.002499268,0.00007094409,0.00005273012,0.00007955763,0.0001700736,0.00006729091,0.0007385993],"genre_scores_gemma":[0.9928207,0.001624471,0.003363722,0.00003141136,0.00004507175,0.0001169542,0.0002823028,0.00003300219,0.001682384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008626542,"threshold_uncertainty_score":0.002566397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139503563033102,"score_gpt":0.2569178602094529,"score_spread":0.2455228245791219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}