{"id":"W2062743407","doi":"10.1002/1097-0134(20000901)40:4<543::aid-prot20>3.0.co;2-o","title":"Modeling protein density of states: Additive hydrophobic effects are insufficient for calorimetric two-state cooperativity","year":2000,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cooperativity; Chemistry; Statistical physics; Enthalpy; Thermodynamics; Globular protein; Protein folding; Hydrogen bond; Computational chemistry; Crystallography; Molecule; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372091,0.0002860206,0.0003080377,0.0001096188,0.0002049751,0.0000418354,0.0001053257,0.0001761713,0.00002093492],"category_scores_gemma":[0.00009261774,0.0002299457,0.00008982297,0.0002498546,0.0001011328,0.00002540834,0.00005936935,0.0001616697,0.000001548034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002596578,"about_ca_system_score_gemma":0.00007796323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004498234,"about_ca_topic_score_gemma":0.00008316705,"domain_scores_codex":[0.998778,0.0000463931,0.0004078285,0.0002779815,0.0001999598,0.0002898743],"domain_scores_gemma":[0.9991462,0.00001485984,0.0001921255,0.0002748493,0.0002623617,0.0001095689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00394545,0.0002798131,0.0007327833,0.00256015,0.0004680635,0.000003764394,0.0009997881,0.05194372,0.68121,0.0004806921,0.000154644,0.2572211],"study_design_scores_gemma":[0.00325543,0.002202184,0.0006989393,0.0001336278,0.00009526405,0.00002686589,0.000157481,0.5289758,0.4602321,0.002428372,0.001150073,0.0006438121],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8191137,0.0001692635,0.1785162,0.00001404571,0.00008818981,0.001684619,0.0003420791,0.00002292578,0.00004899758],"genre_scores_gemma":[0.9853406,0.00006758641,0.01373434,0.0001647438,0.00009047332,0.00008575642,0.0003943029,0.00002133529,0.0001008476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4770321,"threshold_uncertainty_score":0.9376912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004242679406257823,"score_gpt":0.2057551532292796,"score_spread":0.2015124738230217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}