{"id":"W2062748162","doi":"10.1016/j.euroneuro.2012.09.009","title":"Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response","year":2012,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Alberta","funders":"European Commission","keywords":"Escitalopram; Antidepressant; Cytokine; Tumor necrosis factor alpha; Medicine; Serotonin reuptake inhibitor; Major depressive disorder; Pharmacology; Oncology; Internal medicine; Immunology; Bioinformatics; Biology; Amygdala","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176284,0.0002772337,0.000348655,0.0004784147,0.0002301723,0.0004170471,0.00009046507,0.000280312,0.001384867],"category_scores_gemma":[0.000313105,0.0001394303,0.0002540857,0.0004427846,0.0001568758,0.0001796033,0.0002196638,0.0002982902,0.0002902405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209976,"about_ca_system_score_gemma":0.0002167804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007638558,"about_ca_topic_score_gemma":0.001147231,"domain_scores_codex":[0.9998562,0.00001929273,0.00000889916,0.00004149459,0.0000263297,0.00004772246],"domain_scores_gemma":[0.9998181,0.00003320957,0.00007624879,0.000009498445,0.00003778197,0.00002516407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00186086,0.00006553234,0.04158505,0.0001625301,0.0001169341,0.0003871989,0.0001200847,0.0002499274,0.9459671,0.000145618,0.0002078423,0.009131287],"study_design_scores_gemma":[0.0000686273,0.000794956,0.8543764,0.00005863983,0.0002711305,0.0008700754,0.0006465983,0.002594906,0.137429,0.0005550603,0.002303232,0.00003119888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949444,0.001332423,0.001300587,0.0001381081,0.00002336024,0.0000257213,0.001527742,0.00002404032,0.0006836851],"genre_scores_gemma":[0.9944647,0.00068924,0.001323785,0.0001469037,0.00002092574,0.00005765886,0.001521803,0.00001030692,0.001764761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384867,"threshold_uncertainty_score":0.004632771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244708624833665,"score_gpt":0.2982187449360101,"score_spread":0.2657716586876734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}