{"id":"W2062764964","doi":"10.1177/1087057114527127","title":"Identification of Novel Polyphenolic Inhibitors of Shikimate Dehydrogenase (AroE)","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dehydratase; Pseudomonas putida; Biochemistry; Polyphenol; Shikimate pathway; Chemistry; Dehydrogenase; Arabidopsis thaliana; Shikimic acid; Enzyme; Biology; Aromatic amino acids; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031388,0.00007889717,0.0001052322,0.0000291458,0.0000257965,0.00001072241,0.00008744452,0.00008100006,0.000001831185],"category_scores_gemma":[0.00004354752,0.0000664024,0.00006611623,0.00005496217,0.00005910291,0.0000101952,0.00003081237,0.00002468381,0.000002743072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004589521,"about_ca_system_score_gemma":0.00003808516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000610572,"about_ca_topic_score_gemma":0.0001129701,"domain_scores_codex":[0.9994091,0.00002075663,0.000238233,0.000153291,0.00009033204,0.00008832749],"domain_scores_gemma":[0.9995601,0.000005059845,0.0001632676,0.0002030818,0.00004488062,0.00002362492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002135011,0.00007248926,0.0004816765,0.00003029796,0.0000263966,9.593356e-8,0.00004511594,0.0002215694,0.9969676,0.001426528,0.0005081013,0.000198846],"study_design_scores_gemma":[0.0002507161,0.00006396687,0.0005656744,0.00001455759,0.00002009752,0.000004037757,0.00002325149,0.0002290485,0.9965408,0.0000372061,0.002173451,0.00007716278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903155,0.0005038382,0.008584792,0.00003998477,0.0001434839,0.00007514187,0.00006521738,0.000004052267,0.0002680085],"genre_scores_gemma":[0.9986747,0.00005097688,0.00009123008,0.0000268303,0.0001792511,0.000004629482,0.000245826,0.000008765882,0.0007177949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008493562,"threshold_uncertainty_score":0.2707811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007589272391178081,"score_gpt":0.2288633018232973,"score_spread":0.2212740294321192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}