{"id":"W2062805157","doi":"10.1007/s11102-007-0058-2","title":"Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-I criteria for remission","year":2007,"lang":"en","type":"article","venue":"Pituitary","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Deutsches Krebsforschungszentrum","keywords":"GNAS complex locus; Pathological; Medicine; Internal medicine; Somatostatin; Endocrinology; Acromegaly; Germline mutation; Mutation; Pituitary tumors; Pathology; Growth hormone; Gene; Biology; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004019867,0.0002733917,0.0004004906,0.001452535,0.0003902508,0.0002827052,0.0002266666,0.0003488543,0.0007401733],"category_scores_gemma":[0.001480543,0.0001812414,0.000273385,0.0005193611,0.0005455322,0.0002272534,0.0003448813,0.0002301843,0.0001628896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240897,"about_ca_system_score_gemma":0.0001914149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002046191,"about_ca_topic_score_gemma":0.001753627,"domain_scores_codex":[0.9997199,0.00003909355,0.00003643655,0.00006326295,0.00006290642,0.00007830541],"domain_scores_gemma":[0.998866,0.0004448789,0.0002101784,0.00006860634,0.0000944429,0.0003159734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001488185,0.00007882977,0.9687762,0.00001520695,0.00005270882,0.00276304,0.0002813743,0.0001628002,0.02303071,0.00005619651,0.00005177163,0.003243021],"study_design_scores_gemma":[0.00002350473,0.000445258,0.9884461,0.000002604578,0.00004206062,0.006709002,0.0001956003,0.0004343749,0.003444328,0.00006095158,0.0001880762,0.000008222556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996476,0.00007028611,0.00005038176,0.000008396992,0.000002141528,0.000002458749,0.00004623744,0.000002844104,0.0001695169],"genre_scores_gemma":[0.999785,0.00002445643,0.00004541034,0.000007100873,0.000002463598,0.000001860454,0.0000720616,0.000001862541,0.00005975792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046191,"threshold_uncertainty_score":0.004068494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291975848145825,"score_gpt":0.3333606957605362,"score_spread":0.3041631109459537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}