{"id":"W2062808593","doi":"10.1097/qai.0b013e318160a529","title":"Pharmacokinetics, Safety, and Efficacy of Tipranavir Boosted With Ritonavir Alone or in Combination With Other Boosted Protease Inhibitors as Part of Optimized Combination Antiretroviral Therapy in Highly Treatment-Experienced Patients (BI Study 1182.51)","year":2008,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); University of Toronto","funders":"","keywords":"Ritonavir; Amprenavir; Medicine; Lopinavir; Saquinavir; Regimen; Viral load; Pharmacokinetics; Pharmacology; Concomitant; Internal medicine; Randomization; Combination therapy; Gastroenterology; Clinical trial; Human immunodeficiency virus (HIV); Antiretroviral therapy; Virology; Protease; Chemistry; HIV-1 protease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001508575,0.001178692,0.001567543,0.0004036671,0.0002464144,0.00115863,0.0007743314,0.0009077534,0.002253051],"category_scores_gemma":[0.001559299,0.0006930821,0.0007175629,0.0004554218,0.0005060495,0.0007469559,0.0003489542,0.00210974,0.0006919238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006314859,"about_ca_system_score_gemma":0.0005357438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000668754,"about_ca_topic_score_gemma":0.0009066992,"domain_scores_codex":[0.9988346,0.0006693216,0.0000596805,0.0001824277,0.0001397919,0.0001142817],"domain_scores_gemma":[0.9990996,0.000168175,0.0002727155,0.00008833332,0.00004766925,0.0003234749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.736186,0.0268036,0.04456317,0.0004050228,0.001521012,0.0002657151,0.0003315556,0.002035817,0.09072196,0.0001400112,0.001907014,0.09511917],"study_design_scores_gemma":[0.2122736,0.6359391,0.1290175,0.0000505387,0.001224821,0.001390134,0.00007878235,0.004751725,0.01198678,0.0001444555,0.003034039,0.0001085615],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984229,0.0006015032,0.0001186966,0.00004286503,0.000008627201,0.00007870337,0.0002653401,0.00002084716,0.0004406548],"genre_scores_gemma":[0.997272,0.000277123,0.0005935283,0.0001098873,0.00005278952,0.0001098754,0.001146444,0.00001514391,0.0004232009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002253051,"threshold_uncertainty_score":0.007978201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870420356866213,"score_gpt":0.2755719956910863,"score_spread":0.2568677921224242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}