{"id":"W2062830295","doi":"10.1002/cbic.200900109","title":"Propionate Analogues of Zearalenone Bind to Hsp90","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Fonds der Chemischen Industrie; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Genome Canada","keywords":"Chemistry; Propionate; Zearalenone; Alkylation; Stereochemistry; Alkyne; Geldanamycin; Ring-closing metathesis; Hsp90; Depsipeptide; Enantiomer; Grignard reaction; Metathesis; Biochemistry; Organic chemistry; Mycotoxin; Heat shock protein; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008591568,0.0001037465,0.0002348363,0.0000755071,0.00002111538,0.000005541915,0.00008030387,0.00007438404,0.0001180151],"category_scores_gemma":[0.0001290286,0.0000748104,0.00006940401,0.0002608786,0.00003455814,0.00002432368,0.00002205197,0.00008651998,0.00006061618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002096556,"about_ca_system_score_gemma":0.00003216395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008249956,"about_ca_topic_score_gemma":6.046013e-7,"domain_scores_codex":[0.9993068,0.000005593408,0.0001738429,0.0002203235,0.0001277162,0.0001657167],"domain_scores_gemma":[0.9994767,0.000007707302,0.00004595866,0.0002430669,0.0001220927,0.0001044488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054141,0.0001182283,0.00006561022,0.00005109322,0.00001886845,0.000005909038,0.00007420741,1.03055e-7,0.9718572,0.00006208266,0.00806006,0.01958123],"study_design_scores_gemma":[0.0002760711,0.0002692323,0.005952201,0.00009497481,0.00003238375,0.00001504095,0.00001683921,0.00000143225,0.9833383,0.00005313921,0.009857096,0.0000932827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865696,0.0004898793,0.000003803547,0.009235988,0.00004236825,0.0002481315,0.000008198687,0.00003379936,0.003368245],"genre_scores_gemma":[0.9921985,0.00003767827,0.001528581,0.001109383,0.0001667721,3.347662e-7,0.0000201131,0.000007253572,0.004931342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01948795,"threshold_uncertainty_score":0.305068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450639953784163,"score_gpt":0.2557628266043064,"score_spread":0.2412564270664648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}