{"id":"W2062830295","doi":"10.1002/cbic.200900109","title":"Propionate Analogues of Zearalenone Bind to Hsp90","year":2009,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Fonds der Chemischen Industrie; Knut och Alice Wallenbergs Stiftelse; Wellcome Trust; Genome Canada","keywords":"Chemistry; Propionate; Zearalenone; Alkylation; Stereochemistry; Alkyne; Geldanamycin; Ring-closing metathesis; Hsp90; Depsipeptide; Enantiomer; Grignard reaction; Metathesis; Biochemistry; Organic chemistry; Mycotoxin; Heat shock protein; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006777103,0.0003631375,0.0001798593,0.0001286095,0.00005638829,0.0001777363,0.0002130744,0.000131685,0.001466155],"category_scores_gemma":[0.000123489,0.0001221564,0.0001655844,0.0001644518,0.000131144,0.0001567601,0.0001766644,0.0002967089,0.0005426575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001528373,"about_ca_system_score_gemma":0.00009709725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104643,"about_ca_topic_score_gemma":0.0005607575,"domain_scores_codex":[0.9999399,0.00001204465,0.000005923291,0.000009199931,0.00001397225,0.00001888197],"domain_scores_gemma":[0.9999366,0.00001182742,0.00002010509,0.000008845029,0.00000840264,0.00001423545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566652,0.00001118042,0.000095433,0.00002837604,0.000005016088,0.00006935666,0.000009226121,0.0001845289,0.9976318,0.00007295182,0.00001945652,0.001715974],"study_design_scores_gemma":[0.00001707384,0.0003801039,0.0006997213,0.000003762745,0.000009227684,0.0001207877,0.00001146687,0.0001638425,0.9953098,0.00002743687,0.003252585,0.000004178027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911103,0.002458363,0.003305525,0.00006743936,0.00002707803,0.00004046032,0.0003017382,0.00006084498,0.002628314],"genre_scores_gemma":[0.9923527,0.001480284,0.002520663,0.0000460802,0.000008054802,0.00001864146,0.0004890277,0.00001699412,0.003067624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466155,"threshold_uncertainty_score":0.004904807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450639953784163,"score_gpt":0.2557628266043064,"score_spread":0.2412564270664648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}