{"id":"W2062835892","doi":"10.1016/j.cyto.2008.01.006","title":"LPS/TLR4 signal transduction pathway","year":2008,"lang":"en","type":"review","venue":"Cytokine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":3239,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"TLR4; Proinflammatory cytokine; Signal transduction; Lipopolysaccharide; Toll-like receptor; Cell biology; Receptor; Stimulation; Immune system; Chemistry; Biology; Immunology; Innate immune system; Inflammation; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004158344,0.001505194,0.001537092,0.001214839,0.0002658709,0.001128762,0.001224336,0.001342664,0.003925782],"category_scores_gemma":[0.0003833108,0.0003650245,0.0003831276,0.001348938,0.0006354967,0.001648718,0.0007665631,0.002560525,0.004639377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007007455,"about_ca_system_score_gemma":0.001319538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005961003,"about_ca_topic_score_gemma":0.001011839,"domain_scores_codex":[0.9998726,0.00001622033,0.00002102288,0.00002623626,0.00004538761,0.00001861301],"domain_scores_gemma":[0.9998503,0.0000385439,0.0000262809,0.000007309811,0.00005545756,0.00002221045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002657667,0.00008297032,0.0001325226,0.008728374,0.00005550913,0.0003839627,0.00002081489,0.0004280405,0.008983449,0.002282489,0.04887703,0.9297591],"study_design_scores_gemma":[0.00003858554,0.00008207204,0.000520155,0.001176192,0.00011794,0.001435708,0.0000406195,0.0001855541,0.002564488,0.001809765,0.992007,0.00002191396],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002928744,0.9933611,0.001115839,0.0007480304,0.001771663,0.00001727574,0.00006914879,0.00003476933,0.002589332],"genre_scores_gemma":[0.001121345,0.9922009,0.001077579,0.000552166,0.0008287104,0.00002655189,0.0001382374,0.000003944634,0.004050551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003925782,"threshold_uncertainty_score":0.01313299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086309541098331,"score_gpt":0.2708654401760169,"score_spread":0.2400023447650336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}