{"id":"W2062855385","doi":"10.1074/jbc.m113.458661","title":"Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Cytosine deaminase; Transfection; Interferon; Innate immune system; Molecular biology; HEK 293 cells; CD14; Cell culture; Biology; Cytotoxicity; Chemistry; Cell biology; Biochemistry; Immune system; In vitro; Virology; Gene; Immunology; Genetics; Flow cytometry; Genetic enhancement","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149154,0.0001885665,0.000176293,0.0001339687,0.0002216352,0.0004248498,0.0001477571,0.0003478223,0.001574217],"category_scores_gemma":[0.0002184413,0.00009946144,0.0002395907,0.0001378809,0.0004327298,0.0001830089,0.0002258186,0.0004169865,0.000571615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005119728,"about_ca_system_score_gemma":0.000461794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272267,"about_ca_topic_score_gemma":0.001696234,"domain_scores_codex":[0.9997701,0.00002376782,0.00002003235,0.00007842959,0.00007068657,0.00003694795],"domain_scores_gemma":[0.9996451,0.00005742132,0.0001146731,0.0000679392,0.00006629915,0.00004857887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001807061,0.000004894176,0.0002712364,0.00002153497,0.000002114909,0.00002571508,0.000004078943,0.00001390307,0.9991602,0.00004715163,0.0000123933,0.0004186244],"study_design_scores_gemma":[0.000005533369,0.00009549109,0.008618136,0.00001216759,0.00001356102,0.0006033465,0.00003004523,0.0004374337,0.9878784,0.000087754,0.002213914,0.000004184741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817489,0.003003525,0.01172387,0.0001313532,0.00004383481,0.00002839317,0.0005950772,0.000242555,0.002482391],"genre_scores_gemma":[0.9953966,0.0003776717,0.001980632,0.0000495439,0.000005125794,0.00001828039,0.0004404848,0.00002753912,0.001704226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574217,"threshold_uncertainty_score":0.005266309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141363231343486,"score_gpt":0.226613621540363,"score_spread":0.2051999892269281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}