{"id":"W2062889937","doi":"10.2165/00003088-200544020-00001","title":"Interactions Between Antiretrovirals and Antineoplastic Drug Therapy","year":2005,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; St. Michael's Hospital","funders":"","keywords":"Pharmacology; Drug interaction; Medicine; CYP2B6; Taxane; Docetaxel; Efavirenz; Drug; Ifosfamide; Pharmacokinetics; Reverse-transcriptase inhibitor; Abacavir; CYP3A4; Oncology; Cancer; Chemotherapy; Internal medicine; Cytochrome P450; Antiretroviral therapy; Immunology; Human immunodeficiency virus (HIV); Viral load; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006969164,0.0009253514,0.001996615,0.001915735,0.0002315886,0.000892921,0.0009794566,0.001084373,0.004624057],"category_scores_gemma":[0.001158219,0.0003215113,0.000618484,0.002051639,0.000358565,0.000840675,0.0004529743,0.001382571,0.001972774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005325447,"about_ca_system_score_gemma":0.000870447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178922,"about_ca_topic_score_gemma":0.002686064,"domain_scores_codex":[0.9996166,0.00008968454,0.00005976364,0.00004675676,0.0001642956,0.00002271684],"domain_scores_gemma":[0.9992715,0.0004330223,0.0001567392,0.00001576322,0.00009449053,0.00002852484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001250816,0.00008862673,0.0002176807,0.01071688,0.0001376519,0.0002375972,0.00002501825,0.0004105103,0.001119526,0.0009997692,0.01565388,0.9702678],"study_design_scores_gemma":[0.00008958005,0.0002216698,0.001902142,0.00385842,0.0004996872,0.003155917,0.0000392694,0.000265676,0.0008832608,0.001285384,0.9877744,0.00002463057],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001401382,0.9983006,0.0001451995,0.0001238347,0.0001029339,0.00000537911,0.00001380258,0.000007339489,0.001160885],"genre_scores_gemma":[0.0010731,0.9974495,0.0003049942,0.0001682384,0.0002028345,0.000007153158,0.00003010713,0.000001201066,0.0007629246],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004624057,"threshold_uncertainty_score":0.01546907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1945344260100718,"score_gpt":0.5078662005472501,"score_spread":0.3133317745371783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}