{"id":"W2062894160","doi":"10.1073/pnas.162172899","title":"Caspase 3 activity is required for skeletal muscle differentiation","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":552,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; University of Ottawa","funders":"","keywords":"Myogenesis; Cell biology; Biology; Myocyte; Skeletal muscle; Caspase; Myosin; Myosin light-chain kinase; Cellular differentiation; C2C12; Apoptosis; Programmed cell death; Biochemistry; Anatomy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577452,0.00005150281,0.00005946496,0.00003695167,0.0001214122,0.000009392939,0.0001865099,0.00007486183,0.00001258325],"category_scores_gemma":[0.000102356,0.00003579223,0.00007328395,0.0001234411,0.0001458127,0.00001822785,0.00004870766,0.00002814858,3.025555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007230353,"about_ca_system_score_gemma":0.000005087145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001196125,"about_ca_topic_score_gemma":5.617437e-8,"domain_scores_codex":[0.9993447,0.000002400557,0.000113726,0.0001584496,0.0003024095,0.00007830194],"domain_scores_gemma":[0.9996418,0.00001053465,0.0001938068,0.000006350714,0.0001319877,0.00001549533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005156279,0.00003204265,0.0001246396,0.00002072587,0.000006200551,2.765922e-10,0.00002968231,0.00001314478,0.9933143,0.003029512,0.0005758703,0.00284868],"study_design_scores_gemma":[0.0001760473,0.00007538416,0.02250157,0.00001101762,0.000008657635,0.000001258617,0.00001580213,0.006466839,0.9627985,0.006841849,0.001049686,0.00005342409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977958,0.00008607162,0.00004778041,0.001053563,0.00002008448,0.00015245,0.00001733923,0.000002463219,0.0008244776],"genre_scores_gemma":[0.9986835,0.00004317131,0.0006223861,0.00008812882,0.00009023042,0.000008829772,5.170367e-7,0.000002670308,0.000460558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03051588,"threshold_uncertainty_score":0.1459565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04150039921607138,"score_gpt":0.2868518835948252,"score_spread":0.2453514843787538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}