{"id":"W2062918288","doi":"10.1371/journal.pone.0087775","title":"Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"High Altitude and Hypoxia","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Natural Science Foundation of China; National Science Foundation","keywords":"Mitochondrial DNA; Mitochondrion; Reactive oxygen species; Intracellular; Hypoxia (environmental); Biology; Genetics; Effects of high altitude on humans; Molecular biology; Oxygen; Chemistry; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009959305,0.0001902861,0.0003846075,0.00005340005,0.00004802695,0.00001250441,0.0001841892,0.0002165044,0.00007365813],"category_scores_gemma":[0.0003186396,0.0001777457,0.00007780227,0.00006542862,0.0001027244,0.000006343703,0.0001224883,0.0001221842,0.000007269154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006171379,"about_ca_system_score_gemma":0.00004728184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002926997,"about_ca_topic_score_gemma":0.00005682616,"domain_scores_codex":[0.9987829,0.00008871229,0.0003209641,0.0003595394,0.0002238314,0.000224087],"domain_scores_gemma":[0.9990132,0.0000332546,0.0002350721,0.0004629363,0.0001177523,0.0001378172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002112594,0.0006468205,0.003540329,0.0001234853,0.0003401033,0.000001054186,0.0001149235,2.548604e-7,0.9943467,0.00005941064,0.00005516841,0.0005604783],"study_design_scores_gemma":[0.001187589,0.0007506186,0.006774578,0.00005867037,0.0001823102,0.000001715035,0.00000878666,0.0000554849,0.9905234,0.0001515411,0.0001180088,0.000187283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988179,0.0003158282,0.0001337276,0.00009821639,0.00003800254,0.0003034726,0.0002034708,0.00001133995,0.00007800668],"genre_scores_gemma":[0.9965906,0.0001298925,0.00268799,0.0000601524,0.0003082518,0.00001530481,0.00003865417,0.00002809029,0.0001410544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003823298,"threshold_uncertainty_score":0.724826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414706063368372,"score_gpt":0.2079997045953204,"score_spread":0.1938526439616367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}