{"id":"W2062921818","doi":"10.1034/j.1600-0773.2003.920508.x","title":"Impact of Five Cytochrome P450 Enzymes on the Metabolism of two Heterocyclic Aromatic Amines, 2‐Amino‐9<i>H</i>‐pyrido[2,3‐<i>b</i>]indole (AαC) and 2‐Amino‐3‐methyl‐9<i>H</i>‐pyrido[2,3‐<i>b</i>]indole (MeAαC)","year":2003,"lang":"en","type":"article","venue":"Pharmacology & Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Indole test; Cytochrome P450; Enzyme; Aromatic amino acids; Metabolism; Chemistry; Amino acid; Biochemistry; Stereochemistry; Cytochrome; Aromatic amine; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833662,0.0003095171,0.000213819,0.0002010736,0.0001633522,0.0002752004,0.0001162004,0.0002155596,0.001298385],"category_scores_gemma":[0.0002994984,0.0001365894,0.0003452718,0.0001678199,0.0001776558,0.0001359492,0.0001346114,0.0002882459,0.0002645381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025534,"about_ca_system_score_gemma":0.0002594851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00315801,"about_ca_topic_score_gemma":0.002491139,"domain_scores_codex":[0.999841,0.00003857951,0.000008366104,0.0000347949,0.00003470873,0.00004263836],"domain_scores_gemma":[0.999841,0.00002537941,0.00003065864,0.00001691472,0.00003528727,0.00005074451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003587837,0.0002128529,0.009482127,0.0001124532,0.00009528443,0.0002176291,0.0000629716,0.0001610782,0.9761795,0.00009722752,0.0001423497,0.009648769],"study_design_scores_gemma":[0.0001132771,0.003204985,0.09198651,0.000008629654,0.0002225116,0.0005211974,0.00009543483,0.000989912,0.9005781,0.00007723868,0.002190203,0.00001198058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974911,0.001256089,0.0004674121,0.00005974609,0.00001699742,0.00001670436,0.0001599601,0.0000182812,0.0005137468],"genre_scores_gemma":[0.9978739,0.0004170873,0.0002519558,0.00001450369,0.000003718754,0.000006342457,0.0002876043,0.000003952456,0.001140958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00315801,"threshold_uncertainty_score":0.00627923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164425459588974,"score_gpt":0.3166082269336554,"score_spread":0.300165680974758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}