{"id":"W2062921818","doi":"10.1034/j.1600-0773.2003.920508.x","title":"Impact of Five Cytochrome P450 Enzymes on the Metabolism of two Heterocyclic Aromatic Amines, 2‐Amino‐9<i>H</i>‐pyrido[2,3‐<i>b</i>]indole (AαC) and 2‐Amino‐3‐methyl‐9<i>H</i>‐pyrido[2,3‐<i>b</i>]indole (MeAαC)","year":2003,"lang":"en","type":"article","venue":"Pharmacology & Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Indole test; Cytochrome P450; Enzyme; Aromatic amino acids; Metabolism; Chemistry; Amino acid; Biochemistry; Stereochemistry; Cytochrome; Aromatic amine; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009077573,0.0008253537,0.001356734,0.000337199,0.0002887052,0.00003067067,0.0007606684,0.0005290975,0.0004493116],"category_scores_gemma":[0.0002423239,0.0006472937,0.0006684024,0.0004428887,0.001052303,0.00002637021,0.0004002897,0.0005598274,0.00002232986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009700151,"about_ca_system_score_gemma":0.000309424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791515,"about_ca_topic_score_gemma":0.000105828,"domain_scores_codex":[0.9947543,0.00140769,0.001176258,0.001146906,0.0004001632,0.001114748],"domain_scores_gemma":[0.997113,0.0006349513,0.0008328907,0.0008593141,0.0002324851,0.0003273014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000493007,0.001007683,0.00213207,0.00007771884,0.001215734,0.00002666828,0.0002841341,0.0005079531,0.9881054,0.0005472327,0.00518459,0.0004178123],"study_design_scores_gemma":[0.004767651,0.00204198,0.03190359,0.00002547774,0.0005339387,0.0002566126,0.0001715363,0.0002116531,0.9560398,0.0003839368,0.003066601,0.0005972217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911027,0.004940669,0.0002139459,0.0003452747,0.000562211,0.001377469,0.0002483816,0.00003067226,0.001178658],"genre_scores_gemma":[0.9954351,0.0008246063,0.0005799467,0.001940792,0.0003335217,0.0003264005,0.00007916559,0.00009047092,0.0003900392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03206559,"threshold_uncertainty_score":0.9995978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0164425459588974,"score_gpt":0.3166082269336554,"score_spread":0.300165680974758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}