{"id":"W2062923632","doi":"10.1016/j.apradiso.2009.04.004","title":"Automated synthesis of an 18F-labelled pyridine-based alkylating agent for high yield oligonucleotide conjugation","year":2009,"lang":"en","type":"article","venue":"Applied Radiation and Isotopes","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Austrian Science Fund; Alberta Cancer Foundation","keywords":"Oligonucleotide; Chemistry; Yield (engineering); Pyridine; Acetamide; Combinatorial chemistry; Radiosynthesis; Solid phase extraction; DNA; Chromatography; Radiochemistry; Extraction (chemistry); Organic chemistry; Biochemistry; In vivo; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003438398,0.0005282444,0.0003767048,0.0002663138,0.0001872296,0.0002904822,0.0004337049,0.0003218619,0.001111929],"category_scores_gemma":[0.0004438734,0.0002673872,0.0002052516,0.0002566218,0.0002051753,0.0002916486,0.0003096024,0.0004606624,0.00104191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596286,"about_ca_system_score_gemma":0.0004909704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003995017,"about_ca_topic_score_gemma":0.0009271853,"domain_scores_codex":[0.9997001,0.00004162658,0.00001957733,0.00006643857,0.0001397581,0.00003252547],"domain_scores_gemma":[0.999801,0.0000490567,0.00005516876,0.00003408125,0.00003570687,0.00002495926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001587393,0.00001057833,0.00005497829,0.00004059586,0.000003991633,0.00003405879,0.000009130058,0.0002284727,0.9909514,0.0001337923,0.00003206445,0.008485016],"study_design_scores_gemma":[0.000008657825,0.0001401383,0.0005132692,0.000003752968,0.00001018539,0.0002075747,0.000003902108,0.001055223,0.9939362,0.00005631936,0.004055841,0.000008910413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5435168,0.004773894,0.4422536,0.0001378171,0.0001162242,0.0007013135,0.0005874446,0.002627125,0.005285847],"genre_scores_gemma":[0.5249735,0.002366562,0.4659527,0.00007572849,0.00004831367,0.0004344691,0.0008684762,0.0001801967,0.005100134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111929,"threshold_uncertainty_score":0.003719747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00811210892946297,"score_gpt":0.2542173867771995,"score_spread":0.2461052778477365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}