{"id":"W2062936585","doi":"10.1126/scitranslmed.3000615","title":"Quinone Oxidoreductase-2–Mediated Prodrug Cancer Therapy","year":2010,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK; Wellcome Trust","keywords":"Prodrug; Cancer; Quinone; Cancer therapy; Medicine; Pharmacology; Oxidoreductase; Cancer research; Chemistry; Stereochemistry; Biochemistry; Internal medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498837,0.0002411905,0.0002379059,0.0001312051,0.00006293107,0.000153612,0.0003254039,0.0002436265,0.001497791],"category_scores_gemma":[0.00009803908,0.00007007008,0.0001669382,0.00008428175,0.0001423341,0.0001119766,0.0001346322,0.0002765942,0.0002913967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004037091,"about_ca_system_score_gemma":0.000116764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003414548,"about_ca_topic_score_gemma":0.0005347742,"domain_scores_codex":[0.9999551,0.00001534061,0.000001793202,0.00001073559,0.000008380644,0.000008773211],"domain_scores_gemma":[0.9999821,0.000003571969,0.000005319752,0.000003218197,0.000001585906,0.000004175052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001700005,0.0006626399,0.00103909,0.0003236152,0.00007664684,0.0003132297,0.00005965374,0.01054069,0.9135581,0.003522269,0.001158246,0.0670459],"study_design_scores_gemma":[0.002653,0.01365708,0.004887655,0.00003073027,0.0001286774,0.001305165,0.00002540621,0.02008409,0.9225286,0.001373093,0.03329992,0.00002651733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690213,0.007525112,0.01831915,0.0002484546,0.00006939945,0.0002814849,0.0004113913,0.0002241823,0.003899528],"genre_scores_gemma":[0.9922702,0.00116595,0.003947832,0.00003746157,0.00001050754,0.00008154815,0.0003981749,0.000006598622,0.00208167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497791,"threshold_uncertainty_score":0.005010664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199475668876768,"score_gpt":0.3562587961111374,"score_spread":0.3363112292234606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}