{"id":"W2062955637","doi":"10.1016/j.humimm.2015.02.002","title":"ER egress of invariant chain isoform p35 requires direct binding to MHCII molecules and is inhibited by the NleA virulence factor of enterohaemorrhagic Escherichia coli","year":2015,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal","funders":"","keywords":"Gene isoform; Escherichia coli; Virulence factor; Chemistry; Cell biology; Virulence; Transcription factor; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002702185,0.0002254728,0.000427902,0.0002155767,0.000183462,0.00001670709,0.000307319,0.0002586847,0.0006599797],"category_scores_gemma":[0.0001384527,0.0001707856,0.00007770368,0.0001934618,0.0004998797,0.0001316741,0.0002023259,0.0003299158,0.0001252257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005838684,"about_ca_system_score_gemma":0.00003804018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006444614,"about_ca_topic_score_gemma":0.0000287743,"domain_scores_codex":[0.9984609,0.0003244255,0.0005339329,0.0003020731,0.00005414752,0.000324478],"domain_scores_gemma":[0.9989327,0.0001199125,0.0003617218,0.0003977264,0.0001620235,0.00002595514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004362716,0.0001228415,0.0008235553,0.00001787036,0.0002233559,0.000001224474,0.003424001,0.000001067935,0.9833522,0.0003443278,0.01046449,0.000788813],"study_design_scores_gemma":[0.00134169,0.001117495,0.004182832,0.00008845258,0.0000421687,0.0000397933,0.002036804,0.00001227788,0.9677669,0.00003191083,0.02313513,0.0002045213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928563,0.003904853,0.0001547388,0.0003051955,0.001128924,0.0003112189,0.00004534542,0.00004057304,0.001252878],"genre_scores_gemma":[0.9953232,0.0001173091,0.00002811211,0.000394728,0.00001252498,0.00002806479,0.00007645841,0.00002103076,0.003998556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01558526,"threshold_uncertainty_score":0.7226315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02839126685698309,"score_gpt":0.2570211010365425,"score_spread":0.2286298341795594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}