{"id":"W2062960628","doi":"10.1016/j.stem.2014.10.012","title":"Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause?","year":2014,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Diabetes Canada; University of Alberta","funders":"","keywords":"Biology; Regenerative medicine; Embryonic stem cell; Stem cell; Insulin; Phenotype; Perspective (graphical); Type 2 diabetes; Cell biology; Cellular differentiation; In vitro; Diabetes mellitus; Bioinformatics; Endocrinology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005708446,0.0003614011,0.0006505678,0.0001981682,0.0001228375,0.00007911223,0.0001533714,0.0001406806,0.0005282983],"category_scores_gemma":[0.00001243318,0.0003221455,0.0001086627,0.0003282598,0.00003511026,0.00006487069,0.0001577762,0.0002116439,0.01004258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008882029,"about_ca_system_score_gemma":0.00006091539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000286716,"about_ca_topic_score_gemma":0.000004604108,"domain_scores_codex":[0.9977805,0.0001298721,0.0004809485,0.0006476174,0.0003649543,0.0005960844],"domain_scores_gemma":[0.997851,0.0003888558,0.000130697,0.000572002,0.000125861,0.0009316365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002658692,0.0002091447,0.001283719,0.0007196777,0.00003645798,0.00002030574,0.001171074,0.0001604015,0.9440001,0.00001075538,0.03893322,0.01318922],"study_design_scores_gemma":[0.002875017,0.0009269925,0.0001823202,0.0002038996,0.000153326,0.000005060217,0.0004513325,0.002121807,0.748259,0.000008471736,0.2443936,0.0004191563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9022505,0.0003343247,0.001125356,0.0003721378,0.0003523644,0.0009585198,0.00001928715,0.000179291,0.09440827],"genre_scores_gemma":[0.8871766,0.00002852454,0.002521655,0.003046832,0.0003362031,0.00004955416,0.00001195003,0.00008478791,0.1067439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2054604,"threshold_uncertainty_score":0.9999231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008474582966641867,"score_gpt":0.2109626172222965,"score_spread":0.2024880342556546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}