{"id":"W2062977162","doi":"10.1126/science.287.5450.125","title":"Modulation of Brain Reward Circuitry by Leptin","year":2000,"lang":"en","type":"article","venue":"Science","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":418,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Leptin; Brain stimulation reward; Stimulation; Hormone; Endocrinology; Internal medicine; Food intake; Brain stimulation; Neuroscience; Hypothalamus; Medicine; Central nervous system; Biology; Psychology; Obesity; Nucleus accumbens","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077899,0.000162798,0.0001882088,0.0001839201,0.0001413623,0.0003746229,0.000113173,0.0001439843,0.0006257366],"category_scores_gemma":[0.000193332,0.00007868384,0.0001064393,0.0000893536,0.0004164071,0.0002394208,0.0002091944,0.0003509158,0.00009102017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003456,"about_ca_system_score_gemma":0.0001705536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998944,"about_ca_topic_score_gemma":0.0009931939,"domain_scores_codex":[0.999922,0.0000185089,0.000004373519,0.00001417926,0.00002098722,0.00001983656],"domain_scores_gemma":[0.9999368,0.000008104589,0.0000203422,0.000005769838,0.0000114044,0.00001747824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004287149,0.00003102201,0.0009512032,0.00005220797,0.00001814443,0.0001418153,0.00002759628,0.0001607108,0.9838732,0.0009774718,0.00009385057,0.01324399],"study_design_scores_gemma":[0.0002234776,0.002785033,0.1061042,0.00009042634,0.00008805205,0.00128546,0.0003068109,0.003306852,0.8723762,0.004966446,0.00843074,0.00003627412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910247,0.00386672,0.002194435,0.0002306685,0.00002460741,0.00000820991,0.00004714921,0.00002290367,0.002580608],"genre_scores_gemma":[0.994957,0.002591453,0.001513172,0.0000580682,0.00001755604,0.00001380815,0.00005237492,0.000004544516,0.0007920408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006257366,"threshold_uncertainty_score":0.002507508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756237407964172,"score_gpt":0.2625871706358281,"score_spread":0.2450247965561864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}