{"id":"W2062989231","doi":"10.1016/j.bbrc.2011.03.013","title":"Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells","year":2011,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Precursory Research for Embryonic Science and Technology; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Reprogramming; Somatic cell; Ataxia-telangiectasia; Cell biology; Biology; Genome instability; Induced pluripotent stem cell; Molecular biology; Cell; DNA damage; Cancer research; Genetics; Gene; DNA; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491226,0.0003345837,0.0004192762,0.0005301744,0.0002010995,0.0005900532,0.0004271767,0.0004626499,0.002562845],"category_scores_gemma":[0.0003131775,0.0002904936,0.0003799416,0.0003025318,0.0002460346,0.0003177635,0.0003521706,0.0009100101,0.0008041093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296385,"about_ca_system_score_gemma":0.0001863584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003573689,"about_ca_topic_score_gemma":0.0003679366,"domain_scores_codex":[0.9994899,0.00007193111,0.0001276341,0.00009584099,0.0001409614,0.00007373501],"domain_scores_gemma":[0.9996133,0.0001306436,0.0001053302,0.00006199256,0.0000235464,0.00006516913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007242081,0.00003162796,0.0001950838,0.00001402908,0.00001046335,0.00008223126,0.00001374432,0.00009566826,0.9981425,0.000124775,0.00004734052,0.00117013],"study_design_scores_gemma":[0.0000097097,0.00007488002,0.002782303,0.000004175174,0.00002338096,0.0003486233,0.00002000131,0.0008702142,0.9945257,0.00004850787,0.001288493,0.00000409513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938424,0.0006009123,0.003063614,0.00009416888,0.00003232385,0.0000177664,0.0005738264,0.0001588181,0.001616204],"genre_scores_gemma":[0.9951612,0.0003884178,0.0009447418,0.00004505916,0.00000831345,0.00002305615,0.0006598107,0.0000816204,0.002687905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562845,"threshold_uncertainty_score":0.008573592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0771199799396349,"score_gpt":0.3456406995046383,"score_spread":0.2685207195650033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}