{"id":"W2062989231","doi":"10.1016/j.bbrc.2011.03.013","title":"Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells","year":2011,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Precursory Research for Embryonic Science and Technology; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Reprogramming; Somatic cell; Ataxia-telangiectasia; Cell biology; Biology; Genome instability; Induced pluripotent stem cell; Molecular biology; Cell; DNA damage; Cancer research; Genetics; Gene; DNA; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000863565,0.0001700684,0.0001901504,0.0001557152,0.0002686032,0.00005570745,0.0008878954,0.0001553723,0.000009224921],"category_scores_gemma":[0.0007081751,0.0001521234,0.00005702497,0.0006758,0.001150209,0.00001000926,0.001759947,0.0004158188,0.00002970556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005144241,"about_ca_system_score_gemma":0.0001253594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004582953,"about_ca_topic_score_gemma":0.00007282754,"domain_scores_codex":[0.9977354,0.0003546957,0.0002917371,0.0006751054,0.0003245857,0.0006185037],"domain_scores_gemma":[0.9979044,0.0001739025,0.00003281868,0.001280951,0.0002056848,0.0004022481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127415,0.000690424,0.0046045,0.00003797841,0.00000687878,0.000003197518,0.000176237,3.032169e-7,0.9912506,0.0001967559,0.0001035883,0.002802077],"study_design_scores_gemma":[0.0004407093,0.000581193,0.02934861,0.00004355988,0.000008350164,0.0000100913,0.0002774888,0.0002757074,0.9667016,0.0002621644,0.001761736,0.0002887878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961264,0.002051524,0.00006792109,0.0002905779,0.000009369882,0.0005569287,0.00002743496,0.00001851049,0.0008513231],"genre_scores_gemma":[0.9963701,0.0008853824,0.002409713,0.00003369429,0.00002533417,0.0001201521,0.00007600011,0.0000173233,0.00006228443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02474411,"threshold_uncertainty_score":0.6203414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0771199799396349,"score_gpt":0.3456406995046383,"score_spread":0.2685207195650033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}