{"id":"W2063002707","doi":"10.1111/jne.12207","title":"Mutational Analysis of the Genes Encoding RFAmide‐Related Peptide‐3, the Human Orthologue of Gonadotrophin‐Inhibitory Hormone, and its Receptor (<scp>GPR</scp>147) in Patients with Gonadotrophin‐Releasing Hormone‐Dependent Pubertal Disorders","year":2014,"lang":"en","type":"article","venue":"Journal of Neuroendocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Horticultural and Herbal Science, Rural Development Administration; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Hypogonadotrophic hypogonadism; Biology; Endocrinology; Internal medicine; Gene; Genetics; Hypogonadotropic hypogonadism; Kisspeptin; Gonadotropin-releasing hormone; Hypothalamus; Hormone; Luteinizing hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322564,0.0003563754,0.0002275427,0.0007697171,0.0002880188,0.0001939178,0.000189537,0.0004816302,0.001881352],"category_scores_gemma":[0.0008484821,0.0002030458,0.0002996798,0.0004993061,0.0003329276,0.0001384312,0.0001881604,0.0002989008,0.0001842427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117805,"about_ca_system_score_gemma":0.0001111421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001226774,"about_ca_topic_score_gemma":0.000765904,"domain_scores_codex":[0.9998047,0.00004250324,0.00002087024,0.00006096122,0.0000353488,0.00003560795],"domain_scores_gemma":[0.9995568,0.0001646086,0.0001558763,0.00002032999,0.0000245187,0.00007785572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007847472,0.0000942609,0.9655517,0.00003915456,0.0000795853,0.007239765,0.0004021146,0.000104519,0.02125903,0.00006984398,0.0001055306,0.004269737],"study_design_scores_gemma":[0.00002751905,0.0002877501,0.9829253,0.000008051177,0.00005837083,0.01472636,0.0002090244,0.0002113524,0.001275194,0.00003797067,0.000226885,0.00000626035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996651,0.00009938607,0.00006253315,0.000007890203,0.000001969292,0.000004039791,0.00005919696,0.000001630899,0.00009814194],"genre_scores_gemma":[0.9997359,0.00003985847,0.00007027167,0.000007126738,0.000004142678,0.000003409225,0.00006695618,0.000001269476,0.0000709813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881352,"threshold_uncertainty_score":0.006293774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006952135223950106,"score_gpt":0.217402054458132,"score_spread":0.2104499192341819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}