{"id":"W2063017874","doi":"10.1038/sj.tpj.6500196","title":"Investigation of polymorphism in the MDR1 gene and antidepressant-induced mania","year":2003,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Mania; Antidepressant; Bipolar disorder; Internal medicine; Genotype; Medicine; Polymorphism (computer science); Allele; Psychiatry; Major depressive disorder; Pharmacology; Psychology; Gene; Genetics; Biology; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005626844,0.0003364083,0.0003923024,0.0006779853,0.0002760479,0.0002726613,0.0002312344,0.0003867817,0.001295579],"category_scores_gemma":[0.001364198,0.000248551,0.0003897313,0.0006066727,0.0003021657,0.0001913443,0.0001855312,0.000540835,0.0001353458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206518,"about_ca_system_score_gemma":0.0001859892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009620283,"about_ca_topic_score_gemma":0.0009366642,"domain_scores_codex":[0.9995281,0.0002934922,0.00003570349,0.00005573076,0.0000545178,0.00003242248],"domain_scores_gemma":[0.9991804,0.0003459352,0.0002692112,0.00006909854,0.00005054807,0.00008483935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02506145,0.001684566,0.8330604,0.0001701236,0.001378302,0.002589665,0.0005521642,0.0001960215,0.1177422,0.0003604819,0.0001763575,0.01702838],"study_design_scores_gemma":[0.0002797443,0.007400459,0.9835491,0.00001003677,0.0004414851,0.00198909,0.0001478742,0.0002439169,0.005372664,0.0001178061,0.0004373138,0.00001054874],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993156,0.0003321484,0.000073797,0.00003381226,0.00000349207,0.000007406523,0.00005452914,0.000001452679,0.0001778032],"genre_scores_gemma":[0.9992694,0.0002256478,0.0001172887,0.00003499105,0.000008374689,0.000007970026,0.00008693343,0.000001627825,0.0002478334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295579,"threshold_uncertainty_score":0.004334092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06620867713146601,"score_gpt":0.30983957243618,"score_spread":0.243630895304714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}