{"id":"W2063028686","doi":"10.3390/life5021301","title":"Genetic Code Evolution Reveals the Neutral Emergence of Mutational Robustness, and Information as an Evolutionary Constraint","year":2015,"lang":"en","type":"article","venue":"Life","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Genetic code; Neutral mutation; Evolvability; Robustness (evolution); Biology; Computational biology; Neutral theory of molecular evolution; Constraint (computer-aided design); Molecular evolution; Amino acid; Proteome; Codon usage bias; Code (set theory); Genetics; Computer science; Genome; Gene; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007572317,0.0002138823,0.0003813819,0.00057977,0.0004910827,0.001143994,0.0003852555,0.0007825121,0.001207934],"category_scores_gemma":[0.00565155,0.0002027023,0.000389748,0.0003758737,0.002313965,0.001928004,0.0009510421,0.001161947,0.0001570059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00102353,"about_ca_system_score_gemma":0.0004451355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000813769,"about_ca_topic_score_gemma":0.000469084,"domain_scores_codex":[0.9995714,0.0001175139,0.00002130724,0.0001238618,0.0001214572,0.00004443038],"domain_scores_gemma":[0.9981737,0.0009105747,0.0003488533,0.0003078023,0.0001171468,0.0001419838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000345154,0.00006083551,0.01430128,0.0002530646,0.0001359573,0.001040796,0.0005597353,0.100337,0.1637604,0.671468,0.0009945168,0.04674338],"study_design_scores_gemma":[0.00005060085,0.0002141534,0.01465888,0.00004430506,0.00007832977,0.001003897,0.0002390285,0.3261095,0.03089513,0.6192958,0.007312761,0.00009754472],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8490884,0.0008511106,0.131009,0.002786933,0.0000688272,0.00002404736,0.0001290723,0.0002636585,0.01577889],"genre_scores_gemma":[0.9833572,0.000271416,0.01531171,0.0001642932,0.00003393281,0.00001493704,0.00004813133,0.00004176673,0.0007567033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207934,"threshold_uncertainty_score":0.007426262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582842835839812,"score_gpt":0.2450244633821442,"score_spread":0.2291960350237461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}