{"id":"W2063035654","doi":"10.1016/s0014-5793(00)01521-0","title":"α‐Actinin‐2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells","year":2000,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Medical Research Council Canada","keywords":"HEK 293 cells; Cell biology; Actin cytoskeleton; Cytoskeleton; Ion channel; Gating; Actin; Actinin; Biology; Chemistry; Biophysics; Receptor; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671779,0.000136835,0.0001291323,0.00007207671,0.00008761656,0.00003183676,0.00004994168,0.00008094434,0.0000214972],"category_scores_gemma":[0.00001960004,0.0001461981,0.00004369057,0.0001360225,0.00003152078,0.000008236677,0.00003275113,0.00006708499,0.00001856409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002642404,"about_ca_system_score_gemma":0.00001139997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004673401,"about_ca_topic_score_gemma":0.00002740504,"domain_scores_codex":[0.9990984,0.00006089608,0.0001749714,0.0003349908,0.0001187365,0.0002119723],"domain_scores_gemma":[0.9996804,0.000007794463,0.00004202809,0.0001514157,0.00003469086,0.00008365428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000483351,0.0001171886,0.009675345,0.00009834416,0.00005164126,0.000005186073,0.001385742,0.195581,0.683628,0.00003083943,0.04529544,0.06364787],"study_design_scores_gemma":[0.002211671,0.0003578167,0.02858263,0.0002157836,0.00004589005,0.00001757942,0.0005913488,0.06568746,0.5712597,0.00006368407,0.3296202,0.00134621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905028,0.0002069218,0.006983598,0.001124426,0.0008604474,0.0002369047,0.000006227717,0.00001874402,0.00005987255],"genre_scores_gemma":[0.9970387,0.0001606233,0.0000942327,0.001727106,0.0006387226,0.00001931605,0.0001437971,0.00001877902,0.0001587094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2843248,"threshold_uncertainty_score":0.5961784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058227651971828,"score_gpt":0.2273562578364907,"score_spread":0.2167739813167724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}