{"id":"W2063039550","doi":"10.1016/j.bbamem.2011.09.027","title":"Structural basis for misfolding at a disease phenotypic position in CFTR: Comparison of TM3/4 helix-loop-helix constructs with TM4 peptides","year":2011,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Circular dichroism; Mutant; Chemistry; Folding (DSP implementation); Transmembrane domain; Helix (gastropod); Protein folding; Biophysics; Transmembrane protein; Crystallography; Biochemistry; Amino acid; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003843086,0.0004549357,0.0004059681,0.0002417444,0.0004473421,0.0004004952,0.0003477658,0.0008694975,0.001786574],"category_scores_gemma":[0.0005843477,0.0002138802,0.0008501452,0.0001508367,0.0004940637,0.0003053897,0.0002861903,0.0009839761,0.0004905124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003978731,"about_ca_system_score_gemma":0.0003889663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090072,"about_ca_topic_score_gemma":0.00068528,"domain_scores_codex":[0.9997489,0.0000675971,0.00004735395,0.00003689244,0.0000501162,0.00004910179],"domain_scores_gemma":[0.9992642,0.0001978996,0.0002342284,0.00005265128,0.0001048701,0.0001462646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004160784,0.00004277065,0.0005222191,0.0000431207,0.00001949522,0.000433854,0.00004489868,0.0004737902,0.9972798,0.0001707403,0.00004577301,0.0005075323],"study_design_scores_gemma":[0.00006963161,0.000521798,0.007981256,0.00001583489,0.00008828574,0.001184339,0.000107251,0.004082392,0.9846847,0.0001187136,0.001120276,0.00002555085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975268,0.0001804813,0.001609116,0.00008522026,0.00003978307,0.00002186509,0.0001585604,0.00002728548,0.0003507886],"genre_scores_gemma":[0.9979262,0.00009219164,0.001244292,0.00008929284,0.000008573074,0.00001419654,0.0002693537,0.00002620245,0.0003296014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786574,"threshold_uncertainty_score":0.005976617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03784395823551141,"score_gpt":0.3106263099798612,"score_spread":0.2727823517443498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}