{"id":"W2063090066","doi":"10.1126/science.1090772","title":"Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation","year":2003,"lang":"en","type":"article","venue":"Science","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":555,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"RHOA; CDC42; Cell biology; Lamellipodium; Cell polarity; RAC1; Motility; Ubiquitin ligase; Rac GTP-Binding Proteins; Pseudopodia; GTPase; Small GTPase; Chemistry; Actin cytoskeleton; Polarity (international relations); Actin; Cell migration; Biology; Cytoskeleton; Cell; Ubiquitin; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003247132,0.00003146741,0.00002785056,0.00002347966,0.0001235552,0.00001512347,0.00003828737,0.00002568906,0.00000349132],"category_scores_gemma":[0.000115765,0.00003005297,0.00001293211,0.00007129289,0.00003143527,0.00001938127,0.0000150335,0.00001567031,2.43382e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007797798,"about_ca_system_score_gemma":0.00002870746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000350601,"about_ca_topic_score_gemma":0.000002023536,"domain_scores_codex":[0.9996536,0.00001056927,0.00008610315,0.0001136298,0.00006672485,0.00006936578],"domain_scores_gemma":[0.9997441,0.00000335538,0.00006702627,0.00006755834,0.0000975826,0.0000204308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003961799,0.00001125574,0.000054982,0.00000912103,3.209103e-7,2.221323e-9,0.00001671886,0.000002890929,0.9985522,0.0006356154,0.00008220635,0.0006307404],"study_design_scores_gemma":[0.0000997375,0.0000766697,0.0001914062,0.000003113451,0.000001946329,0.000001021433,0.00004670446,0.002882879,0.9879296,0.0003875722,0.008343361,0.00003592766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8844841,0.0001284916,0.1148021,0.00002422767,0.00005670864,0.0001804247,0.000006249694,0.00000191508,0.0003158698],"genre_scores_gemma":[0.9942364,0.00002030707,0.005507084,0.00001333755,0.000007732224,0.000007155787,0.00005009903,0.000002203852,0.0001557289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097523,"threshold_uncertainty_score":0.1225524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007337477025518921,"score_gpt":0.2370938624294394,"score_spread":0.2297563854039205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}