{"id":"W2063105808","doi":"10.1159/000094743","title":"In vitro Binding and Functional Studies of Ac-RYYRIK-ol and Its Derivatives, Novel Partial Agonists of the Nociceptin/Orphanin F/Q Receptor","year":2006,"lang":"en","type":"article","venue":"Neurosignals","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"Università degli Studi di Ferrara; Nemzeti Kutatási és Technológiai Hivatal","keywords":"Nociceptin receptor; NOP; Partial agonist; Chemistry; Chinese hamster ovary cell; Agonist; GTPgammaS; Receptor; Endogenous agonist; Radioligand; Ligand (biochemistry); G protein-coupled receptor; Intrinsic activity; Stereochemistry; Biochemistry; Opioid peptide; Opioid; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971888,0.0003171721,0.0003733688,0.0001151337,0.0001091446,0.0001406945,0.0002978415,0.0002068611,0.001215134],"category_scores_gemma":[0.0001997849,0.000103556,0.0002320932,0.0002203224,0.0001366401,0.0001137608,0.0001254725,0.0003529885,0.0004712941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204274,"about_ca_system_score_gemma":0.0001651816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277207,"about_ca_topic_score_gemma":0.001228423,"domain_scores_codex":[0.9998208,0.00004720904,0.0000110177,0.00002704446,0.00004712582,0.00004695656],"domain_scores_gemma":[0.999889,0.00003726867,0.00002102257,0.000008287579,0.00001626533,0.00002818807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004471415,0.00007506787,0.0001537624,0.0001213559,0.0000181149,0.00008293209,0.00002301977,0.0004769668,0.9962991,0.00006376045,0.00004810862,0.002190521],"study_design_scores_gemma":[0.00007385493,0.00420919,0.00501964,0.00001442225,0.00006987777,0.001033133,0.00006375454,0.002381309,0.9815049,0.00003957299,0.005568916,0.00002153786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895851,0.007084743,0.001429519,0.00003711941,0.00001793752,0.00002976573,0.0004667706,0.00001604428,0.001332913],"genre_scores_gemma":[0.9880095,0.004966185,0.002911043,0.00006242151,0.00002371571,0.00003207074,0.001779139,0.00001238088,0.002203561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277207,"threshold_uncertainty_score":0.004065037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07864923293001416,"score_gpt":0.2914796989346273,"score_spread":0.2128304660046132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}