{"id":"W2063105808","doi":"10.1159/000094743","title":"In vitro Binding and Functional Studies of Ac-RYYRIK-ol and Its Derivatives, Novel Partial Agonists of the Nociceptin/Orphanin F/Q Receptor","year":2006,"lang":"en","type":"article","venue":"Neurosignals","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"Università degli Studi di Ferrara; Nemzeti Kutatási és Technológiai Hivatal","keywords":"Nociceptin receptor; NOP; Partial agonist; Chemistry; Chinese hamster ovary cell; Agonist; GTPgammaS; Receptor; Endogenous agonist; Radioligand; Ligand (biochemistry); G protein-coupled receptor; Intrinsic activity; Stereochemistry; Biochemistry; Opioid peptide; Opioid; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009862278,0.0001488081,0.000284856,0.00006533681,0.0001155906,0.00001492573,0.0001161406,0.0000367164,0.00002004809],"category_scores_gemma":[0.000351132,0.0001092283,0.0000472839,0.0002618077,0.0003472115,0.0001480744,0.0001986945,0.0001392647,0.000002679332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007923332,"about_ca_system_score_gemma":0.00001926688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001252452,"about_ca_topic_score_gemma":0.000002057836,"domain_scores_codex":[0.9987406,0.0001568979,0.0003420113,0.0003684637,0.0001846583,0.000207381],"domain_scores_gemma":[0.9991168,0.0004706679,0.0002381391,0.0001006654,0.00004475048,0.00002898241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520333,0.00009216288,0.0003448527,0.00004008288,0.000002962996,0.000002589853,0.00007666456,0.00003512045,0.9977053,0.001234645,0.0002409865,0.00007260412],"study_design_scores_gemma":[0.0004796666,0.0001599253,0.01425005,0.00003483408,0.000006978894,0.00001173008,0.00003302622,0.00006850905,0.9842439,0.0001573371,0.0004648871,0.00008912442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991338,0.0001174429,0.000003859064,0.0002004397,0.000200102,0.0001976787,0.00006776673,0.000009676951,0.00006923381],"genre_scores_gemma":[0.9991369,0.00009345346,0.00002689499,0.0004676293,0.00008114008,0.00001141362,7.239006e-7,0.00001487341,0.0001670356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0139052,"threshold_uncertainty_score":0.4454199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07864923293001416,"score_gpt":0.2914796989346273,"score_spread":0.2128304660046132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}