{"id":"W2063125594","doi":"10.1007/s12272-013-0200-9","title":"Synthesis and anti-HIV-1 screening of novel N′-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides","year":2013,"lang":"en","type":"article","venue":"Archives of Pharmacal Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases","keywords":"EC50; Human immunodeficiency virus (HIV); Aryl; Chemistry; Stereochemistry; Cytotoxic T cell; In vitro; Virology; Organic chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172063,0.0003731202,0.0003202986,0.0002260004,0.0001517295,0.000134005,0.0004346958,0.0001901401,0.001935641],"category_scores_gemma":[0.0001069065,0.000206594,0.000180421,0.0001797889,0.0001543011,0.0001340045,0.0001547697,0.0002946246,0.0004760237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973428,"about_ca_system_score_gemma":0.0002504899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006150362,"about_ca_topic_score_gemma":0.002031855,"domain_scores_codex":[0.9999095,0.00001996356,0.000008526727,0.00001709702,0.00002124727,0.000023592],"domain_scores_gemma":[0.9999454,0.000009496557,0.00001084158,0.000007840157,0.00001220789,0.00001425617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001906891,0.0000966743,0.0001355929,0.00006451897,0.000008998614,0.00008222643,0.00001719306,0.0002657366,0.995538,0.0000907173,0.0000789647,0.003430684],"study_design_scores_gemma":[0.0001314093,0.001341258,0.001819972,0.000007544242,0.00002777316,0.0002495869,0.00001980959,0.0005977795,0.9927873,0.00002538014,0.002985118,0.000007119324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863673,0.00231092,0.006151719,0.0001395531,0.00005448951,0.0001755359,0.000767907,0.0001354583,0.003897207],"genre_scores_gemma":[0.9859093,0.00235196,0.005761291,0.00006793316,0.00002201997,0.0001027826,0.001393586,0.00001472874,0.004376448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935641,"threshold_uncertainty_score":0.006475329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.10625861588536,"score_gpt":0.3632251084705452,"score_spread":0.2569664925851851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}