{"id":"W2063184008","doi":"10.1074/jbc.m110.151647","title":"Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; University of California, Irvine; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; University of Missouri-Kansas City; University of Missouri; National Institutes of Health; Wayne State University","keywords":"Furin; CREB; PHEX; Chemistry; Cell biology; Molecular biology; Transcription factor; Biochemistry; Biology; Gene; Endocrinology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426792,0.000106512,0.0003099815,0.00003185601,0.00002064904,0.000004427968,0.0000399124,0.0001965432,0.0002934496],"category_scores_gemma":[0.0002003012,0.00007043236,0.0001455027,0.00007500902,0.00009794902,0.00004220031,0.000007349666,0.0001751841,7.271241e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001218471,"about_ca_system_score_gemma":0.00004672907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006844059,"about_ca_topic_score_gemma":0.000001078914,"domain_scores_codex":[0.9990516,0.00001898608,0.0005564032,0.0001004998,0.0001755948,0.00009689779],"domain_scores_gemma":[0.9990315,0.00003190725,0.0005387115,0.00009064746,0.0002289708,0.00007821612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000381407,0.0004028201,0.008375723,0.00009045853,0.00003985632,0.00002696717,0.00004756703,0.00001834596,0.9901792,0.00001221762,0.00007820849,0.0003471682],"study_design_scores_gemma":[0.002153628,0.0004952311,0.00281523,0.0001063218,0.00009330075,0.0002019972,0.00007385596,0.0002243503,0.9934821,0.0001566834,0.0001325192,0.000064783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973693,0.001846079,0.0003916236,0.0000639521,0.00003627406,0.0001273104,0.0000325916,0.000005550003,0.0001273481],"genre_scores_gemma":[0.9977722,0.0000562047,0.00174168,0.000004874958,0.00009695031,0.000003197991,0.00009719399,0.000005573495,0.0002220931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005560493,"threshold_uncertainty_score":0.3213067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641738801079594,"score_gpt":0.2599507713536067,"score_spread":0.2435333833428108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}