{"id":"W2063211660","doi":"10.1038/mt.2014.17","title":"Enriched Protein Screening of Human Bone Marrow Mesenchymal Stromal Cell Secretions Reveals MFAP5 and PENK as Novel IL-10 Modulators","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Allergy and Infectious Diseases; National Institutes of Health; B.P. Koirala Institute of Health Sciences; Western University; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Shriners Hospitals for Children","keywords":"Stromal cell; Biology; Bone marrow; Mesenchymal stem cell; Cell; Secretory protein; In vivo; In vitro; Molecular biology; Cell culture; Cell biology; Gene; Computational biology; Cancer research; Immunology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005934795,0.0001917349,0.0003037519,0.0001460737,0.0001889225,0.0000171521,0.0001444449,0.0002317162,0.0003874305],"category_scores_gemma":[0.00006216939,0.0001814045,0.0001086165,0.0001126801,0.0001434941,0.00008308939,0.00005121329,0.0001890897,0.00004449714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001155837,"about_ca_system_score_gemma":0.00002540581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007538484,"about_ca_topic_score_gemma":0.000001322961,"domain_scores_codex":[0.9986415,0.0003618318,0.0003503142,0.000310342,0.00006671479,0.0002692947],"domain_scores_gemma":[0.999219,0.00003982112,0.0002028177,0.0004282541,0.00008504192,0.00002506587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002618943,0.00008038541,0.0001213705,0.00001577471,0.00008966352,0.000002387592,0.0002552145,0.000009320249,0.9934791,0.003417803,0.00003904767,0.002228083],"study_design_scores_gemma":[0.002342287,0.0007186818,0.004506154,0.00003217074,0.00001972446,0.00002300241,0.00007683919,0.0000407396,0.9881786,0.0004889015,0.003371064,0.0002018686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916469,0.001412506,0.005235413,0.0001698026,0.00004297151,0.0004338655,0.000006684657,0.00003955638,0.001012288],"genre_scores_gemma":[0.9961117,0.00002164083,0.000540353,0.00007906048,0.00001573844,0.00003669714,0.0001157005,0.00002714508,0.003051961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005300489,"threshold_uncertainty_score":0.7397459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009205371349678429,"score_gpt":0.230502938022534,"score_spread":0.2212975666728556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}