{"id":"W2063296278","doi":"10.1038/nchembio.599","title":"A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":531,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; Centre for Addiction and Mental Health; University of Toronto; SickKids Foundation; Structural Genomics Consortium","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Epigenetics; Methyltransferase; Histone H3; Gene knockdown; Biology; Histone methyltransferase; Histone; microRNA; Gene; Psychological repression; Cell biology; Regulation of gene expression; Gene expression; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001995797,0.0002109063,0.0002386758,0.00005762305,0.00002764621,0.000008792301,0.0001442286,0.00117093,0.00001488204],"category_scores_gemma":[0.0001591921,0.0001896238,0.0000658077,0.0001541287,0.0002041182,0.000004337259,0.0001036007,0.0005618674,0.000002619212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002137428,"about_ca_system_score_gemma":0.00005640402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003053842,"about_ca_topic_score_gemma":0.00001954797,"domain_scores_codex":[0.9987444,0.00009300351,0.0001911574,0.0005862166,0.00006352177,0.000321737],"domain_scores_gemma":[0.9995352,0.00003828431,0.0000517569,0.0001888896,0.00007238665,0.0001134698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376351,0.0001325385,0.003296074,0.00001613208,0.00002261923,0.000001902642,0.00008122698,1.114185e-7,0.992057,0.000158394,0.00001889716,0.003977466],"study_design_scores_gemma":[0.0006201421,0.0001398212,0.001488274,0.000006880166,0.00001211593,0.000004188749,0.00000526962,0.000009147122,0.9947328,0.001438625,0.001315695,0.0002270374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962773,0.001874486,0.000680223,0.00007922126,0.00007579213,0.0002141012,0.00002255023,0.00001403418,0.0007622931],"genre_scores_gemma":[0.9966205,0.0002246201,0.002739893,0.0001640803,0.0001178266,0.00002736848,0.00006849779,0.00001895184,0.00001821832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003750429,"threshold_uncertainty_score":0.9031288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084590105000946,"score_gpt":0.2534775399008105,"score_spread":0.2426316388508011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}