{"id":"W2063296278","doi":"10.1038/nchembio.599","title":"A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":531,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; Centre for Addiction and Mental Health; University of Toronto; SickKids Foundation; Structural Genomics Consortium","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Epigenetics; Methyltransferase; Histone H3; Gene knockdown; Biology; Histone methyltransferase; Histone; microRNA; Gene; Psychological repression; Cell biology; Regulation of gene expression; Gene expression; Genetics; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000388016,0.000541694,0.0004377997,0.0003247113,0.0003740203,0.0003044185,0.0006499193,0.0008727184,0.004164555],"category_scores_gemma":[0.0003820959,0.0004164483,0.0003892881,0.0002574577,0.0005308201,0.0002733175,0.0004679998,0.001185976,0.0006531274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005977611,"about_ca_system_score_gemma":0.0006788219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221704,"about_ca_topic_score_gemma":0.002482944,"domain_scores_codex":[0.9997228,0.00004957677,0.00001368487,0.00006934934,0.00006265131,0.0000819373],"domain_scores_gemma":[0.9997759,0.0000922524,0.00003824837,0.00003671889,0.00001861872,0.00003823163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001543001,0.00003162463,0.00007675268,0.00004274412,0.00001139197,0.00003992303,0.00001423616,0.00009328724,0.9970708,0.0005592595,0.0001339013,0.001771751],"study_design_scores_gemma":[0.000021387,0.0001913839,0.0002244328,0.000002138043,0.000008185153,0.00004605767,0.000006142282,0.0002189248,0.9977277,0.00004528933,0.001505693,0.00000266757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518148,0.002525565,0.02880441,0.001241067,0.0003338823,0.0002149698,0.0007957827,0.000719569,0.01354979],"genre_scores_gemma":[0.9787623,0.001312933,0.009565142,0.0003792851,0.00006378944,0.0001524288,0.0007342359,0.0001084638,0.008921395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004164555,"threshold_uncertainty_score":0.01393181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084590105000946,"score_gpt":0.2534775399008105,"score_spread":0.2426316388508011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}